三七对两种大鼠血浆凝血过程的血液流变学模型参数的影响  

Effect of notoginseng saponin on parameters of hemorheology in two kinds of rat model for plasma coagulation

作　　者：李永平[1] 王立明[1] 郭志荣[1] 廖福龙[2] 

机构地区：[1]廊坊师范学院物电学院,065000 [2]中国中医科学院, 北京100700

出　　处：《国际生物医学工程杂志》2010年第3期176-179,共4页International Journal of Biomedical Engineering

基　　金：河北省科技支撑计划项目（09276161） 志谢本文的前期工作是在北京大学工学院博士生导师、已故教授严宗毅老师的精心指导下完成的,谨对严老师表示诚挚的敬意和深切的怀念.中国科学院中药研究所的李文、温瑞兴等同志参加了有关的实验工作,提供了有关的数据,谨致谢意

摘　　要：目的有人用旋转黏度计在恒定的低切变率下测定了抗凝血样复钙后的切应力随时间变化的曲线。笔者针对这一方法提出了一种凝血过程的血液流变学理论模型，本研究试图寻求并分析2种大鼠血浆（正常血浆、富血小板血浆）在给予三七皂苷前后其各自模型参数的差异。方法应用模型拟合实验数据，比较所得2种大鼠血浆给予三七皂苷前后其各自的模型参数，从中找出差异。结果模型参数中的大部分没有变化，只有少数几个参数发生变化，有的甚至变化很大。结论模型拟合出的各种模型参数均有明确的血液流变学意义，通过模型参数的变化可以分析出血浆受药物影响前后其凝固性能的差异。Objective An experimental approach was proposed to measure the shear stress change over time（curve） of an anti-coagulative blood sample after recalcification under a constant shear rate in a rotational viscometer and a hemorheological model was established based on this approach. In this paper, the effects of noto- ginseng saponin on the hemorhelogical model parameters of normal rat plasma and platelet-rich rat plasma were investigated. Methods The hemorheological model was introduced to fit the experimental data and the changes in hemorhelogical model parameters of two kinds of rat plasma before and after the addition of notoginseng saponin were investigated. Results Most of the parameters of the theoretic model did not change, while only a few of parameters changed, and of which several significant change happened. Conclusion The experimental results indicate that the fitted model parameters have clear meaning of hemorheology, and the model parameters can be used for evaluating the influence of a drug on plasma clotting.

关 键 词：血液流变学 模型 血浆 三七 参数 

分 类 号：R-332[医药卫生] R28