间质干细胞与血脑屏障通透性的研究进展  

Research progress in mesenchymal stem cell and blood-brain barrier permeability

作　　者：周丽萍[1] 余勤[1] 段延平[1] 

机构地区：[1]浙江中医药大学生物工程学院, 杭州310053

出　　处：《国际生物医学工程杂志》2010年第3期191-192,I0001,I0002,共4页International Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目（30940028）;浙江省自然科学基金资助项目（Y2080787）

摘　　要：间质干细胞可通过脑实质、血液和脑脊液等移植方式进入脑组织，修复损伤组织，促进神经功能恢复，是治疗中枢神经系统疾病的理想种子细胞；但血脑屏障存在着特殊结构，研究间质干细胞与血脑屏障通透性的相关性，使更多间质干细胞穿过血脑屏障。综述了间质干细胞与血脑屏障通透性的最新研究进展。Mesenchymal stem cells（MSCs）, which can be introduced in brain tissue by the strategies of brain parenchyma, blood and neurolymph transplantation, to repair tissue injury and promote functional recovery of neural system, have been considered as the ideal seed cells for the treatment of central nervous system diseases. However, as the special structure exists in the blood-brain barrier, study on correlation between MSCs and blood-brain barrier permeability will make it possible for more MSCs to pass the barrier to perform the treatment. This paper gives a review on the latest research development in the field.

关 键 词：间质干细胞 血脑屏障 通透性 体外模型 

分 类 号：R74[医药卫生—神经病学与精神病学]