血浆同型半胱氨酸水平与脑梗死近期复发关系的临床研究  

Clinical study on the relationship between the level of plasma homocysteine and recurrent cerebral infarction

作　　者：胡丹[1] 何志勇[1] 王小同[1] 竺飞燕[1] 陈瑛[1] 王炼[1] 张雄[1] 

机构地区：[1]温州医学院附属第二医院脑科中心与康复中心,浙江温州325027

出　　处：《温州医学院学报》2010年第4期371-373,共3页Journal of Wenzhou Medical College

基　　金：温州市科技局重大科研基金资助项目(Y20070038)

摘　　要：目的:探讨高同型半胱氨酸血症(Hhcy)与脑梗死患者近期复发的关系。方法:245例急性脑梗死患者均测定血浆同型半胱氨酸(Hcy)水平,并按Hcy水平分为Hhcy组与非Hhcy组,分别随访6个月观察其脑梗死近期复发情况并分析其影响因素。结果:245例急性脑梗死患者有96例(占39.2%)血浆Hcy水平高于正常。Hhcy与非Hhcy二组患者之间年龄、性别、高血压、糖尿病、血脂异常、BMI、吸烟饮酒率、NIHSS评分等一般情况差异无显著性(均P>0.05);Hhcy组脑梗死近期复发率(11.4%)显著高于非Hhcy组(4.7%),差异有显著性(P<0.05)。结论:Hhcy可增加脑梗死患者近期复发可能性。Objective：To probe the relationship between the level of plasma homocysteine（Hcy） and recurrent cerebral infarction.Methods：The level of plasma homocysteine was detected in 245 patients suffered from acute cerebral infarction.According to the level of plasma homocysteine,patients were divided into hyperhomocysteinemia（Hhcy） group and normal homocysteinemia（NHcy） group.The recurrence of cerebral infarction of both groups was observed during a follow-up of 6 months.Results：There were 96 patients with elevated level of plasma homocysteine in the Hhcy group.Then,the other 149 patients were put into the NHcy group.The two groups had no statistical difference in general information such as age,gender,hypertension,diabetes,BMI and NIHSS score（P 〉0.05）.While the recurrent rate of the Hhcy group was 11.4% and significantly higher than that of the NHcy group（P 〈0.05）,which was 4.7%.Conclusion：Hyperhomocysteinemia can increase the possibility of recurrent after previous cerebral infarction.

关 键 词：同型半胱氨酸 脑梗死 复发 

分 类 号：R743.3[医药卫生—神经病学与精神病学]