B7-H4在前列腺癌中的表达及其临床意义  

Expression of B7-H4 in prostate cancer and its clinical significance

作　　者：钱韵[1] 姚航平[2] 沈玲[2] 程林芳[2] 张立煌[3] 

机构地区：[1]浙江大学免疫学研究所,浙江杭州310058 [2]浙江大学医学院附属第一医院,浙江杭州310003 [3]浙江大学城市学院医学与生命科学学院,浙江杭州310015

出　　处：《浙江大学学报（医学版）》2010年第4期345-349,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金资助项目(30972777);浙江省科技计划资助项目(2009C33150)

摘　　要：目的:研究共刺激分子B7-H4在前列腺癌中的表达情况及其临床意义。方法:应用免疫组织化学染色,检测B7-H4分子在前列腺癌中的表达情况,并评价其与临床病理特征的关系。结果:前列腺癌组织中B7-H4在胞浆和(或)胞膜弥漫表达,表达量显著高于正常前列腺组织(P<0.05)。B7-H4在临床肿瘤分级较高患者的前列腺癌组织中,表达显著强于临床肿瘤分级较低患者的前列腺癌组织。结论:B7-H4在前列腺癌组织中表达上调,与患者肿瘤分级密切相关。异常表达的B7-H4在肿瘤的发生、进展中起到一定作用,有望成为肿瘤新的诊断和预后判断指标,封闭肿瘤组织中的B7-H4有可能成为肿瘤免疫治疗的新策略。Objective： To investigate the expression of B7-H4 in prostate cancer tissue and the relationship between the expression and the clinicopathological features.Methods： Immunohistochemical staining was used to detect the expression of B7-H4 in prostate cancer tissue.And the relationship between the expressions and pathology was evaluated.Results： The B7-H4 was diffusely expressed in cytoplasm and/ or membrane of the prostate cancer tissue;the expression was much higher than that in normal prostate tissue（P 0.05）.The expression of B7-H4 in the prostate cancer tissue was higher in patients with higher tumor grade.Conclusion： B7-H4 may be used as an new indicator for the diagnosis and prognosis of prostate cancer and a novel target for immunotherapy.

关 键 词：前列腺肿瘤/病理学 前列腺肿瘤/诊断 免疫疗法 B7-H4 前列腺癌 免疫组织化学 肿瘤分级 

分 类 号：R737.25[医药卫生—肿瘤]