免疫功能异常在儿童复发性腮腺炎发病中的作用  

Role of immunologic abnormality in recurrent parotitis in children

作　　者：阮文华[1] 苏吉梅[1] 叶笑味[1] 黄晓佳[1] 吴志芳[1] 

机构地区：[1]浙江大学医学院附属儿童医院口腔科,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2010年第4期419-423,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省中医药青年基金项目(2006Y040)

摘　　要：目的:探讨免疫功能异常对儿童复发性腮腺炎(RPC)发病的影响。方法:对来就诊的复发性腮腺炎患儿进行免疫功能检测,并分不同年龄组与正常儿童的免疫功能相比较。结果:复发性腮腺炎患儿6岁及6岁以上年龄组CD4+T细胞明显低于6岁以下年龄组(P<0.05),而IgG则显著性高于6岁以下组(P<0.05)。与正常儿童相比,6岁以下组复发性腮腺炎患儿CD8+T细胞以及IgG、IgE、IgA及C3明显升高(P<0.01),而CD4+T细胞明显降低(P<0.01);6岁及6岁以上组复发性腮腺炎患儿CD8+T细胞、IgE(P<0.01)及C3(P<0.05)明显高于正常对照组,CD4+T细胞明显低于正常组(P<0.01)。6岁以下组的RPC患儿IgE值、CD8+T细胞都非常显著地高于6岁及6岁以上组的正常组儿童(P<0.01)。结论:RPC患儿存在着免疫功能异常现象,超敏反应及细胞免疫功能紊乱可能参与了儿童复发性腮腺炎的疾病过程。Objective： To investigate the relationship between immune function and the recurrent parotitis（RP） for children.Methods： The children diagnosed as RP were divided into two groups： aged under 6y and over 6y and the immune function were measured and compared with that of normal children.Results： For RP children the ratio of CD4＋ T cell in over 6y group was significantly lower than that in under 6y group（P0.05）,while IgG value in over 6y group was higher than that in under 6y group（P0.05）.Compared with normal children,RP children in under 6y group had higher CD8＋ T cell ratio and IgG,IgE,IgA and C3 value（P0.01） and lower CD4＋ T cell ratio（P0.01）,while RP children over 6y group,they had higher CD8＋ T cell ratio,IgE value（P0.01） and C3（P0.05）,lower CD4＋ T cell ratio than those in control group（P0.01）.IgE value and CD8＋ T cell ratio in under 6y group were higher than those over 6y control group（P0.01）.Conclusion： Impaired immune function may play an important role in the recurrent parotitis in children.

关 键 词：CD4-CD8比值 免疫 细胞 免疫球蛋白A 抗体生成 腮腺炎/免疫学 儿童 复发性腮腺炎 体液免疫 

分 类 号：R781.7[医药卫生—口腔医学]