VEGF和D2-40在食管鳞癌中的表达及其临床意义  

Expression and clinical significance of VEGF and D2-40 in human esophageal squamous carcinoma

作　　者：刘冰华[1,2] 张彧婷[2] 姜杨[2] 姜寰宇[1] 马晶[1] 

机构地区：[1]哈尔滨医科大学解剖学教研室,黑龙江哈尔滨150081 [2]齐齐哈尔医学院解剖学教研室,黑龙江齐齐哈尔161000

出　　处：《解剖科学进展》2010年第4期354-356,共3页Progress of Anatomical Sciences

摘　　要：目的观察血管内皮生长因子(VEGF)和D2-40在人食管鳞癌组织内的表达,探讨VEGF的表达与食管鳞癌组织淋巴管密度(LVD)及淋巴结转移之间的关系。方法将67例食管鳞状细胞癌分为有淋巴结转移和无淋巴结转移两组,免疫组化法检测食管鳞癌组织中VEGF和D2-40的表达,并与正常组进行对照。结果 VEGF蛋白主要表达于癌细胞胞浆内,D2-40表达于癌组织内淋巴管内皮细胞,在食管鳞癌的癌组织中VEGF的阳性表达率和D2-40阳性淋巴管密度均高于正常食管组织(P<0.05),且有淋巴结转移组的阳性表达率高于无淋巴结转移组(P<0.05)。结论 VEGF的高表达可能与食管鳞癌的淋巴管生成和淋巴道转移密切相关。Objective To observe the expression of vascular endothelial growth factor （VEGF） and D2-40 in human esophageal squamousl carcinoma to investigate the relationship between the lymphatic vessel density（LVD） and lymph node metastasis. Methods The expression of VEGF protein and D2-40 was examined by immunohistochemistry in 67 cases of esophageal squamous cell carcinoma which were devided into lymph node metastasis group and nonmetastatic group. Results The expression of VEGF protein was mainly detected in cytoplasm of malignant cells and D2-40 in endothelium of lymphatic vessels. The positive rates of VEGF protein and D2-40 positive lymphatic vessel density were significantly higher in lymph node metastatic esophageal squamous carcinoma compared with nonmetastatic group（P0.05）, and significantly higher in lymph node metastatic group than in nonmetastatic group（P0.05）. Conclusion The high expression of VEGF may closely related to the generation of lymphatic vessel and lymph node metastasis in esophageal squamous cell carcinoma.

关 键 词：血管内皮生长因子 D2-40 人食管鳞癌 

分 类 号：R735.1[医药卫生—肿瘤]