胆固醇酯水解酶与缺血性脑血管病的关系  

Relationship of cholesterol ester hydrolase with ischemic cerebrovascular disease

作　　者：王瑞[1] 罗俊生[1] 关宁[1] 霍小川[1] 

机构地区：[1]辽宁医学院附属第一医院神经外科,辽宁锦州121001

出　　处：《解剖科学进展》2010年第4期367-369,共3页Progress of Anatomical Sciences

摘　　要：缺血性脑血管病是威胁人类健康的常见病、多发病,其主要病理基础是脑供血血管动脉粥样硬化性狭窄。胆固醇酯(CEs)在单核巨噬细胞内过度聚集形成泡沫细胞是动脉粥样硬化病变的显著特征。胆固醇酯水解酶(CEH)能够将细胞内胆固醇酯水解为游离胆固醇而排出细胞,维持细胞内脂质的稳定,抑制单核巨噬细胞的泡沫化。国外研究发现,胆固醇酯水解酶(CEH)的表达水平同动脉粥样硬化的易感性呈负相关。目前国内对CEH在AS斑块形成中的作用研究甚少,本文就近年国外对胆固醇酯水解酶在动脉粥样硬化形成中的作用研究进展作一综述。Ischemic cerebrovascular disease,caused by the cerebrovascular atherosclerotic angusty, is a common illness of therating human healthy. Formation of foam cell via cholesterol esters over-gathered in mononuclear macrophage is the dominant feature of atheromatosis. Cholesterol ester hydrolase （CEH） retains intercellular lipidic homeostasis and refrains the formation of the foam of mononuclear macrophage via hydrolester intercelluar cholesterol ester to free cholesterol. There is a reverse correlation between the expression level of CEH and the sensitivity of artherosclerosis. At present, there are few researchs about the role of CEH in the progress of formation of AS plaque.In this paper, we reviewed the recent researches on the role of CEH in the formation of AS.

关 键 词：胆固醇酯水解酶 缺血性脑血管病 动脉粥样硬化病变 单核巨噬细胞 动脉粥样硬化形成 细胞内脂质 泡沫细胞 硬化性狭窄 

分 类 号：R743.31[医药卫生—神经病学与精神病学]