多囊卵巢综合征与人类白细胞抗原相关性的研究  

The research on the lnterrelation between polycystic pvarian syndrome and HLA

作　　者：杨冬梓[1] 周俊宜[2] 陈忠良[3] 邝健全[1] 罗超权[2] 姚书忠[4] 

机构地区：[1]中山医科大学孙逸仙纪念医院妇产科,510120 [2]中山医科大学生化教研室 [3]中山医科大学卫生学院流行病学教研室 [4]中山医科大学附属第一医院

出　　处：《广东医学》1999年第2期97-98,共2页Guangdong Medical Journal

摘　　要：目的　探讨多囊卵巢综合征 (PCOS)与人类白细胞抗原 (HLA)相关性。方法　采用多聚酶链反应和寡核苷酸探针杂交技术 (PCR -SSO)对 3 0例汉族PCOS患者和 10 6例汉族无亲缘关系健康个体的HLA -DQA基因进行研究。结果　PCOS组HLA -DQA1 2基因频率显著低于对照组 ,比数比 (OR)值提示该基因为PCOS的抵抗 (不易感 )基因 ;PCOS组HLA -DQA1 1及 3基因频率分布高于对照组 ,HLA -DQA1 3基因频率低于对照组 ,但差异无显著性。结论　PCOS的发病有遗传物质基础 ,HLA -DQA基因分布可能对预测或诊断PCOS具有意义。Objective To study the interrelation between polycystic ovarian syndrome (PCOS) and human leucocyte antigen (HLA). Methods 30 cases of PCOS and 106 unrelated healthy individuals of Chinese Han nationality were included, whose frequency distribution of HLA-DQA genotyping was investigated using PCR-SSO. Results The frequency of HLA-DQA “1 2” allele was lower significantly in PCOS group than the control group, which was indicated by the value of odds ratio (OR) to be the resistant (or insusceptible) gene to PCOS; The frequency of HLA-DQA “1 1” and “3” were higher, “1.3” was lower in PCOS group than the control group, but they were not significant statistically. Conclusion There may be genetic material base of PCOS. The frequency distribution of HLA-DQA genotyping may be of value in the prediction and diagnosis of PCOS.

关 键 词：多囊卵巢综合征 HLA-DQ抗原 等位基因 

分 类 号：R588.602[医药卫生—内分泌] R711.75[医药卫生—内科学]