颅内外动脉狭窄与高同型半胱氨酸血症的关系  

Relationship between Hyperhomocysteinemia and Intracranial and Extracranial Artery Stenosis

作　　者：张丽云[1] 

机构地区：[1]西安高新医院神经内科,西安710075

出　　处：《华西医学》2010年第5期850-851,共2页West China Medical Journal

摘　　要：目的探讨缺血性脑血管病患者高同型半胱氨酸(Hcy)血症与颅内外动脉狭窄的关系。方法 2007年6月2009年12月收治缺血性脑血管病患者90例,根据全脑血管造影检查结果分为颅内外动脉狭窄组和颅内外动脉无狭窄组;颅内外动脉狭窄组依狭窄部位分为单纯颅内动脉狭窄组、单纯颅外动脉狭窄组及颅内外动脉均有狭窄组;分析各组同型半胱氨酸的水平。结果颅内外动脉狭窄组血浆Hcy水平显著高于颅内外动脉无狭窄组(P<0.05);单纯颅内动脉狭窄组、单纯颅外动脉狭窄组及颅内外动脉均有狭窄组血浆Hcy水平均显著高于颅内外动脉无狭窄组(P<0.05)。结论高同型半胱氨酸血症是颅内外动脉狭窄的危险因素,是单纯颅内动脉狭窄及单纯颅外动脉狭窄的共同危险因素。Objective To study the relationship between hyperhomocysteinemia and intracranial and extracranial artery stenosis in patients with ischemic cerebrovascular disease. Methods A total of 90 patients with ischemic cerebrovascular disease were analyzed retrospectively from June 2007 to December 2009. They were divided into intracranial and extracranial artery stenosis group and intracranial and extracranial artery stenosis group according to their DSA findings. Patients with intracranial and extracranial artery stenosis group were divided into simple intracranial stenosis group, simple extracranial stenosis group and both stenosis group according to stenosis location. The plasma homocystein （Hcy） concentrations in each group were analyzed. Results Mean plasma Hcy concentrations were significantly higher in patients with stenosis of intracranial or/and extracranial artery than that in patients without arterial stenosis （P0.01）. Mean plasma Hcy concentrations were significantly higher in patients with simple intracranial stenosis group, simple extracranial stenosis group and both stenosis group than that in the patients without arterial stenosis （P0.01）. Conclusion Hyperhomocysteinemia is a risk factor for the intracranial and extracranial artery stenosis.

关 键 词：颅内外动脉狭窄 高同型半胱氨酸血症 缺血性脑血管病 脑血管造影 

分 类 号：R743.3[医药卫生—神经病学与精神病学]