特发性视神经炎患者治疗后色觉损害  

Color damage in patients with idiopathic optical neuritis after the treatment

作　　者：孙堂胜[1] 阿西木江[1] 魏世辉[1] 

机构地区：[1]解放军总医院眼科,北京100853

出　　处：《中华眼底病杂志》2010年第4期335-338,共4页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的 观察特发性视神经炎（ION）患者治疗后色觉损害情况。方法临床确诊的ION患者26例44只眼纳入本研究。所有患者均经糖皮质激素类药物大剂量冲击治疗，治疗后视力恢复至1.0以上，神经系统MRI及血液检查等无异常。另选取24名健康体检者作为正常对照组。ION患者治疗后8～10周，平均（9．64±1．39）周后进行色觉检查。采用Farnsworth Munsell-100型色觉测试仪检测ION患者患眼的总错误得分及红、绿、蓝各色彩的错误得分，原值及取平方根后进行统计学分析；并与对照组色觉检测结果进行比较。结果10N组总错误得分及总错误得分平方根与对照组相比，差异均有统计学意义（t=3．079，3．133；P=0．0033，0．0026）。红、绿、蓝3种色彩错误得分在原值水平比较分析时，两组差异无统计学意义（t=1．91，1.15，1．62；P=0．061，0．26，0．11），但将原值平方根后显示2组红色觉得分差异有统计学意义（t=2．21，P=0．031）。结论ION患者经治疗后虽然视力恢复，但其色觉损害仍然存在，其中红色觉在视力恢复后最早出现明显损害。Objective To detect the color damage in patients with idiopathic optical neuritis （ION） after the treatment. Methods A total of 26 ION patients （44 eyes） with ION whose visual acuity were above 1.0 were collected. All the patients had undergone the treatment of incretion and had the visual acuity more than 1.0 after the treatment. The results of MRI and blood examination were normal. Another 24 healthy persons were selected as the normal control. Total error scores （TES） and each error score of red, green and blue were measured via Farnsworth Munsell-100 hue tester. The TES origin scores and their square roots were used for a statistical analysis. The results of the two groups were compared. Results There were significant differences in TES and its square roots between ION group and the normal control group （t=3.079,3.133;P=0.0033,0.0026）. The differences in the level of error scores of each color between the tow groups were not significant （t= 1.91, 1.15, 1.62 P=0.061, 0.26, 0.11）; but the differences in the square roots of red color between the two groups were statistically （t=2.21, P=0. 031）. Conclusion After the treatment, the visual acuity of ION patients increases, but the color damage still exist red color damage happens first.

关 键 词：色觉缺陷/病理生理学 视神经炎/并发症 视神经炎/治疗 色觉试验/利用 

分 类 号：R774.61[医药卫生—眼科] R770.423[医药卫生—临床医学]