High performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP stationary phase  

作　　者：Yan Wang Qing Qiang Yao Mu Zou Wang 

机构地区：[1]Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China [2]Institute of Materia Medica,Shandong Academy of Medical Science,Jinan 250062,China

出　　处：《Chinese Chemical Letters》2010年第7期860-863,共4页中国化学快报（英文版）

摘　　要：A method of high performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP（α_1-acid glycoprotein） stationary phases has been established.The absolute configurations of（-）clausenamide and（＋）clausenamide are 3S, 4R,5R,6S and 3R,4S,5S,6R,respectively.The present method has been used to analyze the（-）clausenamide and（＋）clausenamide and its analogues such as the major metabolite and synthetic derivatives of clausenamide.A method of high performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP（α_1-acid glycoprotein） stationary phases has been established.The absolute configurations of（-）clausenamide and（＋）clausenamide are 3S, 4R,5R,6S and 3R,4S,5S,6R,respectively.The present method has been used to analyze the（-）clausenamide and（＋）clausenamide and its analogues such as the major metabolite and synthetic derivatives of clausenamide.

关 键 词：ENANTIOMERS （-）Clausenamide （＋）Clausenamide Chiral-AGP HPLC 

分 类 号：O658[理学—分析化学] TQ577.13[理学—化学]