直肠癌组织CRD-BP表达及其临床意义的研究  

CRD-BP and its clinical significance in human rectal carcinomas tissues

作　　者：王启远[1] 李坤[1] 胡波[2] 孙海娇[2] 孙静阳[2] 周长江[1] 

机构地区：[1]大连大学附属新华医院消化内科,辽宁大连116021 [2]大连大学附属新华医院病理科,辽宁大连116021

出　　处：《中华肿瘤防治杂志》2010年第12期930-932,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨人直肠癌组织中CRD-BP的表达及其临床意义。方法:应用免疫组织化学SP法检测60例直肠癌组织、20例癌旁正常黏膜组织及20例直肠腺瘤伴不典型增生组织中CRD-BP的表达情况。结果:直肠癌组织CRD-BP阳性表达率为60%(36/60),显著高于直肠腺瘤伴不典型增生组织的25%(5/20)和癌旁正常组织的0,差异有统计学意义,χ2值分别是7.355和21.818,P值分别是0.007和0.000。直肠腺瘤伴不典型增生组织CRD-BP阳性表达与癌旁正常组织比较,差异有统计学意义,χ2=5.714,P=0.017。CRD-BP表达与性别、年龄、病理分化程度、直肠癌部位及形态无明显相关,P>0.05;CRD-BP的表达与Duke分期、有无淋巴结转移及有无远处转移差异有统计学意义,P<0.05。结论:直肠癌组织中CRD-BP处于过度表达状态,与直肠癌的发生发展及侵袭转移密切相关。OBJECTIVE：To detect the expression of CRD-BP and its clinical significance in human rectal carcinomas.METHODS：The expression of CRD-BP was detected by the immunohistochemistry SP staining method in 60 rectal carcinomas tissues,20 paraneoplastic tissues and 20 rectal adenoma with atypical hyperplasia tissues.RESULTS：The positive rates of CRD-BP in rectal carcinomas tissues,rectal adenoma tissues and paraneoplastic tissues were 60%（36/60）,25%（5/20） and 0,respectively.The positive rate of CRD-BP in rectal carcinomas tissues was significant higher than the rates in rectal adenoma tissues and paraneoplastic tissues （χ^2 values were 7.355 and 21.818,respectively;P values were 0.007 and 0.000,respectively）.The positive rate of CRD-BP in rectal adenoma tissues was significant higher than that in paraneoplastic tissues （χ^2=5.714,P=0.017）.The CRD-BP expression in rectal carcinomas tissues was significantly correlated with the Duke stage,lymph node metastasis and remote metastasis （P〈0.05）,but not correlated with the gender,age,histology grade,tumorous location and tumorous morphology （P〈0.05）.CONCLUSION：CRD-BP plays a significant role in the occurrence,development and metastasis of human rectal carcinomas.

关 键 词：直肠肿瘤 不稳定编码区结合蛋白 免疫组织化学 

分 类 号：R735.37[医药卫生—肿瘤]