多发性骨髓瘤骨病的诊断与治疗新进展  

Diagnosis and treatment of bone disease of multiple myeloma

作　　者：王晶 (综述) 陈文明(审校)[2] 

机构地区：[1]黑龙江省大庆油田总医院血液内科,163001 [2]首都医科大学附属北京朝阳医院血液科北京市多发性骨髓瘤医疗研究中心

出　　处：《白血病．淋巴瘤》2010年第7期443-446,共4页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金面上项目（30872982）

摘　　要：约90%的多发性骨髓瘤（MM）患者存在骨损害.常规X线检查只有在30%的骨小梁缺失后才能发现溶骨性损害,对于初诊MM患者的分期,常规X线检查仍是＂金标准＂.在发现小的溶骨性病变方而CT扫描比常规X线检查更敏感.但对怀疑有椎体压迫的患者应行磁共振成像（MRI）或CT扫描.同位素骨扫描常常低估MM患者骨损害的程度.MM骨病的治包括双磷酸盐、新的靶向治疗、外科手术、放射治疗等治疗措施.Up to 90 % of multiple myeloma patients can develop to osteolytic lesions. Although the conventional X radiography can only demonstrate the lytic bone disease when 30 % of the trabecular bone loss, it still remains the ＂gold standard＂ of the staging procedure of newly diagnosed myeloma patients. CT scans are more sensitive than X radiography for detecting small lytic lesions. MRI or CT is the choice of diagnosis to assess suspected cord compression. Technicium-99m bone scan in patients with myeloma usually underestimate the extent of bone damage. Treatments of myeloma bone disease include bisphosphonate therapy, novel targeted agents, surgical intervention and radiation therapy.

关 键 词：多发性骨髓瘤 骨病医学 诊断 治疗 

分 类 号：R733.3[医药卫生—肿瘤]