原发性肝癌患者HBV感染模式及与AFP相关性分析  

Analysis of HBV infection and its relationship with AFP in primary hepatocarcinoma

作　　者：王宇[1] 崔巍[1] 刘沛[1] 

机构地区：[1]中国医科大学附属第一医院传染科,辽宁沈阳110001

出　　处：《中国现代医学杂志》2010年第13期1994-1996,共3页China Journal of Modern Medicine

摘　　要：目的分析原发性肝癌(PHC)患者主要HBV感染模式及其与血清AFP的关系。方法分析195例PHC患者HBV感染情况及血清AFP水平。结果 HBV感染到临床发生PHC中位时间12.5年,158例HBV-M阳性(81.03%)感染模式以HBsAg阳性(36.71%)及HBsAg、抗-HBe阳性(27.85%)居多。HBV-M阳性组AFP升高比例(73.42%)与阴性组(45.95%)相比差异有统计学意义(P<0.05),两组间AFP值差异具有统计学意义(P<0.05)。结论 PHC与HBV感染有关,应对HBsAg阳性及HBsAg、抗-HBe阳性者高度重视,HBV感染后12年是警惕PHC发生的重要时期。AFP水平受HBV感染影响,临床中应结合病因判断AFP在早期筛查及诊断PHC中的价值。[ Objective ] To analyse the situation of hepatitis B virus infection and the relationship with AFP in primary hepatocarcinoma（PHC）.[Methods] Retrospectively studied the clinical data in 195 cases with PHC. [Results] There were 127 eases with the history of HBV infection, the median was 12.5 years. There were 158 eases （81.03%）with HBV-M positive, in which 36.71% showed only HBsAg positive, 27.85% showed ＂two positive＂（HB- sAg and anti-HBe）. The rate of patients with increased AFP in the group with HBV-M positive was higher than negative, the difference had statistical significance （P 〈0.05）, and the difference of AFP value between these two groups had statistical significance （P 〈0.05）. [Conclusion] HBV infection is important pathogeny to PHC. Patients with HBsAg positive and HBsAg,anti-HBe positive should be paid more attention. Twelve years after HBV infection should be the main period for maintaining sharp vigilance to PHC. The increase of AFP has a close relationship with HBV infection in PHC patients.

关 键 词：原发性肝癌 乙型肝炎病毒 乙型肝炎病毒标志物 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]