WNT5A基因rs566926多态性与中国苏皖地区部分人群非综合征性唇腭裂的相关性  

Relationship between genetic polymorphisms of WNT5A rs566926 and nonsyndromic cleft lip with or without cleft palate in Jiangsu and Anhui districts

作　　者：刘小俊[1] 周小平[2] 崔毓贵[2] 刘嘉茵[2] 程宏宇[1] 万伟东[1] 

机构地区：[1]东南大学附属中大医院整形外科,南京210009 [2]南京医科大学第一附属医院临床生殖医学中心

出　　处：《江苏医药》2010年第13期1495-1498,共4页Jiangsu Medical Journal

基　　金：江苏省卫生厅医学科技发展基金资助项目(H200513)

摘　　要：目的探讨WNT5A基因rs566926位点多态性与中国苏皖地区部分人群非综合征性唇腭裂的相关研究。方法选取100例非综合症性唇腭裂(NSCLP)患儿为实验组,100例正常儿童作为对照组,应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测WNT5A基因rs566926多态性。采用病例对照研究方法进行统计分析并依据临床病理类型进行分类分析。结果两组基因型频数分布有明显差异(P<0.05)。结论 WNT5A基因rs566926位点多态性与中国苏皖地区部分人群NSCLP的发生有相关性,可能是该人群NSCLP发生的易感因素之一。Objective To explore the relationship between nonsyndromic cleft lip with or without cleft palate（NSCL/P） and genetic polymorphism of WNT5A rs566926 in Chinese population of Jiangsu and Anhui districts.Methods One handred NSCL/P patients were selected as group A and 100 normal children were taken as group B.WNT5A rs566926 genotypes were determined by polymerase chain reaction and restriction ragment length polymorphism technique（PCR-RFLP）.The genotype frequency and allele frequency were calculated and debated according to different pathological categories.Results The genotype frequency of two groups was significantly different（P0.05）.Conclusion The genetic polymorphism of WNT5A rs566926 is associated with the development of NSCL/P in Chinese people of Jiangsu and Anhui districts,which may be a susceptible factor for NSCLP development.

关 键 词：非综合征性唇腭裂 基因多态性 WNT5A基因 

分 类 号：R782[医药卫生—口腔医学]