糖尿病视网膜病变实验指标的临床危险性分析  

Clinical risk analysis of experimental indices for diabetic retinopathy

作　　者：张晨光[1] 朱琳琳[1] 赵庆伟[1] 周艳君[2] 吴子钊[1] 李平法[1] 

机构地区：[1]新乡医学院医学检验系,河南省新乡市453003 [2]新乡医学院第一附属医院检验科,河南省卫辉市453100

出　　处：《眼科新进展》2010年第8期768-770,共3页Recent Advances in Ophthalmology

基　　金：河南省科技厅资助项目(编号:623031300)~~

摘　　要：目的探讨糖尿病视网膜病变(diabetic retinopathy,DR)患者实验指标的临床危险性。方法检测51例DR患者(DR组)血糖、血脂、超敏C-反应蛋白、纤维蛋白原和血液流变学等实验室指标,与70例非DR患者(NDR组)的对应结果进行比较。结果与NDR组比较,DR组的高密度脂蛋白胆固醇和红细胞变形指数均降低,分别为(0.78±0.04)mmol.L-1和0.41±0.05,差异均有统计学意义(均为P<0.05);糖基化血红蛋白、超敏C-反应蛋白、血清总胆固醇、红细胞聚集指数均显著升高,分别为9.16%±3.21%、(4.95±1.35)mg·mL-1、(6.16±1.45)mmol.L-1、2.69±0.55,差异均有显著统计学意义(均为P<0.01);糖化血清蛋白、血浆纤维蛋白原、低密度脂蛋白胆固醇、全血低切黏度、血浆黏度均升高,分别为(4.61±1.14)mmol.L-1、(3.66±0.62)g.L-1、(3.95±1.42)1-1mmol.L-1、(12.06±2.59)mPa.s-1、(1.73±0.46)mPa.s-1,差异均有统计学意义(均为P<0.05)。2组间血清C-肽、空腹血糖和甘油三酯比较,差异均无统计学意义(均为P>0.05)。结论血糖、血脂、超敏C-反应蛋白和血液流变学异常是糖尿病发生视网膜病变的危险指标,临床应密切观察DR患者的实验室检查指标。Objective To investigate clinical risk factors of laboratory indices for patients with diabetic retinopathy （DR）. Methods Laboratory testing indicators ,such as blood glucose, blood lipids, high-sensitivity C-reactive protein, fibrinogen and blood rheology indices, were detected on 51 cases with DR （DR group） and 70 cases with non-DR （ NDR group ）, and the results were compared between the two groups. Results Compared with the NDR group, high-density lipoprotein cholesterol and red blood cell deformation index were lowered as （0.78 ± 0. 04）mmol . L-1 and 0. 41 ± 0. 05, respectively, and there were statistical differences （ both P 〈 0.05 ） ; Glycosylated hemoglobin,high sensitivity C-reactive protein, total cholesterol and erythrocyte aggregation index were increased as （9.16 ± 3.21 ） % , （4.95 ± 1.35 ） mg . L - 1, （6.16 ± 1.45 ） mmol. L -1 and 2.69 ± 0.55, and there were significant differences （ all P 〈 0. 01 ） ; Saccharily serum protein, plasma fibrinogen, low-density lipoprotein cholesterol, whole blood low-shear viscosity and plasma viscosity were increased as （4.61 ± 1.14） mmol. L-1,（3.66±0. 62）g . L-1, （3.95 ± 1.42）mmol . L-1, （12.06 ±2.59）mPa . s-1 and （1.73 ± 0.46）mPa .s-1, there were statistical differences （all P 〈 0.05 ）. But no difference was found in C-peptide, fasting blood glucose and triglyceride between the two groups （ all P 〉 0.05 ）. Conclusion Abnormal blood glucose, blood lipids, high-sensitivity C-reactive protein and blood rheology in patients with diabetes meilitus are risk factors for DR, and clinical laboratory indicators should be closely observed in patients with DR.

关 键 词：糖尿病视网膜病变 危险因素 血糖 血脂 血液流变学 超敏C-反应蛋白 

分 类 号：R774.1[医药卫生—眼科]