细胞因子信号抑制因子3与糖尿病视网膜病变  

Suppressor of cytokine signaling 3 and diabetic retinopathy

作　　者：李倩[1] 郑志[1] 许迅[1] 

机构地区：[1]上海交通大学附属上海市第一人民医院眼科,上海市200080

出　　处：《眼科新进展》2010年第8期785-788,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:30872828)~~

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是一种常见的糖尿病慢性并发症,早期的视网膜血管渗漏和晚期的新生血管形成是其重要的病理改变,而血管内皮生长因子以及各种炎症因子、瘦素、血管紧张素II等在其发病中发挥重要作用。细胞因子信号抑制因子3作为调节细胞因子信号通路的一种重要蛋白,通过调节Janus激酶/信号转导转录激活因子(JAK/STAT)信号通路,抑制上述各种因子的作用,成为未来治疗DR的新靶点。本文就细胞因子信号抑制因子3在DR发病中的作用进行综述。Diabetic retinopathy （DR） is a common chronic complication of diabetes mellitus,and with retinal hyperpermeability at early stage and late stage as its pathogenesis characterization. Vascular endothelial growth factor, various inflammatory factors, leptin as well as angiotensin II play key roles in the pathogenesis. Suppressor of cytokine signaling 3, as an important protein to regulate signal pathway of cytokines, becomes a new therapeutic target of DR by ways of regulating Janus kinases/signal transducers and activators of transcription pathway and inhibiting the effects of above-mentioned factors. In this review, we summarize the effects of suppressor of cytokine signaling 3 in pathogenesis of DR.

关 键 词：糖尿病视网膜病变 细胞因子信号抑制因子3 Janus激酶/信号转导转录激活因子 

分 类 号：R774.1[医药卫生—眼科]