精神分裂症患者血清5种元素含量变化的临床观察  

Clinical observation of the changes of five elemental contents in serum in patients with schizophrenia

作　　者：何邦平[1,2] 李东方[1,2] 赵德山[1,2] 盛华[1,2] 余海鹰 崔庶[1,2] 盛杏英[1,2] 姜永良[1,2] 刘龙林[1,2] 

机构地区：[1]第二军医大学基础医学部化学教研室 [2]中国人民解放军精神病研究所

出　　处：《第二军医大学学报》1999年第1期42-44,共3页Academic Journal of Second Military Medical University

摘　　要：目的：探讨精神分裂症患者血清５种元素含量变化与疾病的关系。方法：采用原子吸收光谱法测定６５例精神分裂症患者血清微量元素Ｚｎ，Ｃｕ，Ｆｅ和常量元素Ｃａ，Ｍｇ含量的动态变化。结果：（１）精神分裂症患者血清Ｚｎ和Ｍｇ含量及Ｚｎ／Ｃｕ比值明显低于对照组，而Ｃｕ，Ｆｅ和Ｃａ含量及Ｃａ／Ｍｇ比值明显高于对照组。（２）病程＜３年的患者血清Ｃａ含量明显高于病程３年以上患者（Ｐ＜０．０１）；其他无明显差异（Ｐ＞０．０５）。（３）经氯丙嗪等治疗１４ｄ和２１ｄ，患者Ｚｎ和Ｍｇ含量及Ｚｎ／Ｃｕ比值明显升高，而Ｃｕ，Ｆｅ和Ｃａ含量及Ｃａ／Ｍｇ比值明显降低。结论：精神分裂症患者可能存在Ｚｎ，Ｃｕ，Ｆｅ，Ｃａ和Ｍｇ元素代谢异常，这些元素的代谢异常可能在本病的发生和发展中起一定作用。Objective: To study the relation between the changes of five elemental contents in serum and schizophrenia. Methods: The dynamic changes of the trace elements Zn, Cu, Fe and ordinary elements Ca,Mg were examined in 65 patients with schizophrenia by atomic absorption spectrophotometer. Results: (1)The contents of Zn,Mg and Zn/Cu in patients with schizophrenia were significantly lower than those in controls, while Cu,Fe, Ca and Ca/Mg were significantly higher than those in controls.(2)The content of Ca in schizophrenic patients with course of disease <3 years was significantly higher than those ≥3 years.(3) After 14 and 21 d treatment with chlorpromazine or clozapine, the contents of Zn, Mg and Zn/Cu increased obviously, while Cu, Fe, Ca and Ca/Mg decreased obviously. Conclusion: These findings suggest that the patients with schizophrenia might have an abnormal serum Zn, Cu, Fe, Ca and Mg metabolism.This would play a role in causing and developing schizophrenia.

关 键 词：精神分裂症 血清 微量元素 常量元素 

分 类 号：R749.302[医药卫生—神经病学与精神病学]