大鼠抑郁模型的脑磁共振成像研究  

The nuclear magnetic resonance imaging of brain in the rats of depression model

作　　者：王雪琦[1,2] 路长林[1,2] 李丽云 丁广良[1,2] 胡红兵 卢广[1,2] 叶朝辉 

机构地区：[1]第二军医大学神经科学研究所,神经生物学教研室 [2]中国科学院物理与数学研究所

出　　处：《中华精神科杂志》1999年第1期12-14,共3页Chinese Journal of Psychiatry

摘　　要：目的研究大鼠抑郁模型脑磁共振成像（ＭＲＩ）的变化。方法选择ＯＰＥＮＦＩＥＬＤ法评分相近的５０只成年ＳＤ雄性大鼠随机分为对照组和抑郁组，每组各２５只。应用分养和长期不可预见性中等强度应激所造成的大鼠抑郁模型。以敞箱实验等方法测定动物行为；ＭＲＩＴ２加权象对照研究抑郁大鼠脑内整体形态学及各脑区信号强度的改变。结果与对照组比较，抑郁组大鼠大脑纵裂深度加深［抑郁组（２．０５±０．１６）ｍｍ，对照组（１．８３±０．２１）ｍｍ，Ｐ＜０．０５］、体积扩大［抑郁组（３４３．００±７８．８７）ｍｍ３，对照组（２５８．００±１３．５９）ｍｍ３，Ｐ＜０．０５］。抑郁大鼠边缘系统各脑区Ｔ２加权象信号强度增加。结论提示抑郁大鼠存在脑萎缩，边缘系统各脑区水的流动性增加。Objective To study the changes of magnetic resonance imaging in the brain of a depression model of rat. Methods The depression model of rat was produced by separation and chronic unpredictable mild stress. The behavior of rat was detected by open field test. Nuclear magnetic resonance T2 weighted imaging was used to study the changes of whole brain and intensity of T2 weighted signals of some brain areas in depressed rat. Results The brain rift was enlarged and widened. T2 weighted signals were enhanced in some brain areas of limbic system. Conclusion These data suggest that chronic depression could result in brain atrophy and increase the fluidity of water in some brain areas of limbic system.

关 键 词：疾病模型 抑郁症 大鼠 NMR 成像 

分 类 号：R749.41[医药卫生—神经病学与精神病学]