全身调控一氧化氮水平对多发性关节炎大鼠颞下颌关节的影响  

EFFECTS OF GENERAL NITRIC OXIDE REGULATION ON TEMPOROMANDIBULAR JOINT IN RATS WITH POLYARTHRITIS

作　　者：王海鹰[1] 王丛妙[1] 王德文 王东胜[1] 赵彦萍 

机构地区：[1]解放军总医院 [2]北京军区总医院 [3]军事医学科学院二所

出　　处：《解放军医学杂志》1999年第1期38-40,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：为了观察全身调控一氧化氮（ＮＯ）水平对多发性关节炎大鼠颞下颌关节（ＴＭＪ）的影响，探讨ＮＯ对关节炎症的作用机制，用福氏完全佐剂建立大鼠多发性关节炎模型；分组腹腔注射内源性ＮＯ抑制剂ＮＧ－ｎｉｔｒｉｏ－Ｌ－ａｒｇｉｎｉｎｅ（Ｌ－ＮＮＡ）及生成剂Ｌ－ａｒｇｉｎｉｎｅ（Ｌ－Ａｒｇ）；观察大鼠ＴＭＪ的组织病理学变化。结果表明用Ｌ－ＮＮＡ后ＴＭＪ的炎症反应和破坏程度显著减轻；而用Ｌ－Ａｒｇ后情况则相反，滑膜细胞增生、血管扩张、炎性渗出及软骨破坏均有加重。结果提示：全身调控ＮＯ水平对ＴＭＪ的炎症确有作用；及早恰当地降低ＮＯ水平有利于阻止关节炎症的发展和组织的破坏。To probe into the action of nitric oxide (NO) on the pathogenesis of polyarthritis by observing the effects of general NO regulation on temporomandibular joint (TMJ), The animal model of polyarthritis was established by injecting Freund's complete adjuvant into rats. The endogenous NO inhibitory agent NG nitrio L arginine (L NNA) or the aggravating agent L arginine (L Arg) were injected into the abdominal cavities of different groups of polyarthritic rats seperately. And the histopathological changes of rats TMJ were observed. The results showed that the inflammation and the destruction of the TMJ tissues were abated obviously after taking L NNA; but the conditions of TMJ were exacerbated following the use of L Arg, such as worsening of the synovial cell proliferation, hemangiectasis, inflammatory exudation and destruction of articular cartilage. It was suggested that the general regulation of NO hads some definite effects on the arthritis in TMJ, and the inflammation and destruction of TMJ might markedly be eliminated by decreasing the level of NO properly at an early stage.

关 键 词：一氧化氮 关节炎 颞下颌关节 TMJ 

分 类 号：R782.602[医药卫生—口腔医学]