基质金属蛋白酶与大肠癌侵袭和转移关系的研究进展  

Relationship between matrix metalloproteinase and the invasion and metastasis of colorectal cancer

作　　者：杨昀[1] 蒋永来[1] 季国忠[1] 

机构地区：[1]南京医科大学第二附属医院消化医学中心,南京医学硕士研究生210011

出　　处：《医学研究生学报》2010年第7期771-773,共3页Journal of Medical Postgraduates

基　　金：南京市科技局科技与发展计划项目(200801128)

摘　　要：恶性肿瘤的侵袭和转移是复杂的病理过程,细胞外基质和基底膜降解及新生血管的形成是恶性肿瘤侵袭和转移的关键环节。基质金属蛋白酶(matrix metalloproteinese,MMP)是一组Zn2+依赖性蛋白水解酶,在该环节中起重要作用。近年来,对MMP在大肠癌发生中的作用机制进行了大量基础与临床研究,取得了很多进展。文中就MMP与大肠癌侵袭与转移关系的研究作一综述。Malignant tumor invasion and metastasis is a complex pathological process.Degradation of extracellular matrix and basement membrane and formation of new blood vessels are the crucial element in the tumor invasion and metastasis.Matrix metalloproteinase （MMP） are a group of zinc-dependent enzymes.In recent years,the MMP have been demonstrated that it plays an important role in the progress of colorectal cancer invasion and metastasis.In this review,the current progresses of the relationship between MMP and the invasion and metastasis of colorectal cancer are summarized.

关 键 词：基质金属蛋白酶 大肠癌 侵袭转移 

分 类 号：R735.34[医药卫生—肿瘤]