养阴抗毒胶囊对兔肝VX2移植瘤射频治疗前后cAMP、cGMP及CORT影响的实验研究  

The effect of Yang capsule on the rabbit VX2 liver tumor radiofrequency ablation cAMP,cGMP and CORT in rats

作　　者：姚家久[1] 史恒军[1] 任秦有[1] 白双峰[1] 

机构地区：[1]第四军医大学唐都医院中医科,陕西西安710038

出　　处：《现代肿瘤医学》2010年第8期1491-1494,共4页Journal of Modern Oncology

基　　金：陕西省科学技术研究发展计划项目[编号:2007K09-05(1)]

摘　　要：目的:探讨中药养阴抗毒胶囊对兔肝VX2移植瘤射频消融(RFA)术前后CORT、cAMP、cGMP的动态变化的影响。方法:将40只新西兰大白兔采用移植法建立兔肝移植瘤模型,分为:A组中药干预组、B组RFA组、C组模型组、D组空白组,在B超引导下行RFA治疗,术前1天、术后1、3、5、7天检测血清中CORT、cAMP、cGMP动态变化。结果:RFA后普遍存在cAMP和CORT升高、cGMP降低现象,中药养阴抗毒胶囊可显著升高cAMP、降低cGMP并使CORT在适当范围内波动。结论:中药养阴抗毒胶囊可能通过升高cAMP,降低cGMP而启动人体内第二信使并激活HPA使CORT在适当范围内波动而提高RFA治疗效果。Objective： To explore the CORT,cAMP,cGMP changes of rabbit VX2 liver tumor treated by RFA before and after. Methods： All 40 New Zealand white rabbits were used as liver transplantation tumor model divided into 4 groups A： intervention group;B： RF group;C：model group;D：control group. 1 day before and 1,3,5,7 days after to detect CORT, cAMP, cGMP dynamic change. Rusults： CORT after RFA increased, cAMP and cGMP reduces significantly increase cAMP, reduce the cGMP. Conclusions： Traditional Chinese Medicine of Yin antitoxic capsule may increase cAMP, reduce the cGMP second messenger to activate the human body and activate the HPA so that CORT fluctuations to improve RFA treatment.

关 键 词：VX2肿瘤 射频消融 环一磷酸腺苷、环一磷酸鸟苷 皮质醇 

分 类 号：R73-36[医药卫生—肿瘤]