中国安徽地区白血病患者与HLA-A、B、DRB1基因关联性研究  

Associations of Human Leukocyte Antigen-A,B,DRB1 Genes with Leukemia Patients in Anhui Province of China

作　　者：廖艳秋[1] 朱梅红[1] 王敏[1] 蒋光明[1] 王保龙[1] 

机构地区：[1]安徽医科大学附属省立医院输血科,安徽合肥230001

出　　处：《中国实验血液学杂志》2010年第4期1055-1058,共4页Journal of Experimental Hematology

摘　　要：本研究旨在探讨中国安徽地区人群中白血病的易感性与HLA-A、B、DRB1基因多态性之间的关联。采用聚合酶链反应序列特异性引物(PCR-SSP)方法对安徽地区140例慢性髓系白血病(CML)、84例急性淋巴细胞性白血病(ALL)、90例急性非淋巴细胞性白血病(ANLL)患者以及916名健康的非血缘造血干细胞捐献者作为正常对照组进行了HLA基因分型,分别比较了病人组及正常对照组的HLA-A、B、DRB1位点的基因频率,通过χ2检验进行统计学分析。结果表明,CML患者A2、A11、B58、DR9基因频率较对照组明显升高,DR7基因频率较对照组明显降低;ALL患者A11、B13基因频率明显高于对照组;ANLL患者A24、B58、DR9基因频率较对照组明显升高。结论:HLA-A2、A11、B58、DR9是CML的易感基因,DR7是其拮抗基因;HLA-A11、B13是ALL的易感基因;HLA-A24、B58、DR9是ANLL的易感基因。This study was aimed to investigate the relation of human leukocyte antigen-A, B, DRB1 genes with the susceptibility of population to leukemia in Anhui province of China. The HLA genotypes were analyzed by PCR-SSP in 140 patients with chronic myelocytic leukemia（ CML）, 84 patients with acute lymphoblastic leukemia（ALL）, 90 patients with acute nonlymphocytic leukemia（ANLL） and 916 healthy unrelated donors of hematopoietic stem cell as norreal control admitted to Anhui provincial hospital. The gene frequencies of HLA-A,B, DRB1 between patients and norreal controls were compared, x^2 test was used for statistical analysis. The results showed that as compared with normal controls, the gene frequencies of A2, A11, B58 and DR9 in CML patients all obviously increased, and gene frequency of DR7 decreased; the gene frequencies of All and BI3 in ALL patients were significantly higher than that in normal controis; the gene frequencies of A24 ,B58 and DR9 in ANLL patients were significantly higher than that in normal controls. It is concluded that HLA-A2,All ,B58 and DR9 are predisposing genes of CML patients, DR7 is an antagonistic gene, HLA-A11 and B13 are predisposing genes of ALL patients, HLA-A24, B58 and DR9 are predisposing genes of ANLL patients.

关 键 词：白血病 HIA基因 基因频率 易感基因 拮抗基因 

分 类 号：R733.7[医药卫生—肿瘤]