尼曼-匹克病肝、脾、淋巴结、骨髓细胞的超微结构观察  

ULTRASTRUCTURAL STUDY OF LIVER, SPLEEN, LYMPH NODE, BONE MARROW IN NIEMANN PICK DISEASE

作　　者：吴丽莉[1] 颜永碧[2] 沙继宏[2] 

机构地区：[1]第二军医大学长海医院病理科,上海200433 [2]第二军医大学中心实验室

出　　处：《解剖学杂志》1999年第2期157-159,共3页Chinese Journal of Anatomy

摘　　要：目的 :为了进一步了解尼曼 -匹克病的病理变化。方法 :对 4例尼曼 -匹克病患者的肝、脾、淋巴结、骨髓及外周血标本作电镜观察。结果 :发现病变组织细胞内板层小体的形态呈多形性 ,同时伴有多种细胞器的变化。结论 :着重讨论了板层小体形成与粗面内质网。Objective: To further understand the pathologic changes of Niemann Pick disease. Methods: The biopsy specimens of liver, spleen, lymph node, bone marrow in four patients with Niemman Pick disease were observed by electron microscopy. Results: The ultrastructural study showed that many lamellasomes were pleomorphic and the changes of most organellae were present in abnormal histiocytes. Conclusions: The relationship between the formation of lamellasomes and the alteration of the RER and Golgi complex was discussed.

关 键 词：NIEMANN-PICK病 肝 脾 淋巴 骨髓细胞 超微结构 

分 类 号：R589.902[医药卫生—内分泌]