小儿肾母细胞瘤、髓母细胞瘤多药耐药蛋白的表达及意义  

The expression and significance of Pgp in wilms' tumor and medulloblastoma in children

作　　者：蒙育林[1,2,3] 张国成[1,2,3] 许东亮[1,2,3] 郑跃杰 叶江枫[1,2,3] 何晋 李玉松[1,2,3] 李飚 

机构地区：[1]第四军医大学西京医院儿科 [2]乌鲁木齐军区总医院儿科 [3]第四军医大学病理教研室

出　　处：《第四军医大学学报》1999年第4期344-347,共4页Journal of the Fourth Military Medical University

摘　　要：目的：探讨小儿肾母细胞瘤、髓母细胞瘤中ｐ－糖蛋白的表达和意义．方法：应用ＳＡＢＣ免疫组化方法检测４６例肾母细胞瘤，２５例髓母细胞瘤组织中Ｐｇｐ蛋白的表达．结果：７例（１５．２％）肾母细胞瘤呈阳性反应，１１例（４４．０％）髓母细胞瘤呈阳性反应．在与临床病理指标的相关分析中发现，肾母细胞瘤Ｐｇｐ异常表达与化疗，ＮＷＴＳ－Ⅱ病理分型呈显著性相关（Ｐ＜０．０５），与ＮＷＴＳ－Ⅲ临床病理分期无显著性相关（Ｐ＞０．０５）．髓母细胞瘤Ｐｇｐ异常表达与病理分型无显著性相关（Ｐ＞０．０５）．结论：肾母细胞瘤中Ｐｇｐ表达可通过化疗而诱导，Ｐｇｐ与肾母细胞瘤的病理分型相关，肾母细胞瘤恶变过程中，Ｐｇｐ的表达得到加强，Ｐｇｐ可作为肾母细胞瘤的恶性和预后指标．Ｐｇｐ表达与髓母细胞瘤的病理分型无关．AIM: To study the expression and significance of Pgp in wilms' tumor and medulloblastoma. METHODS: Pgp was detected in 46 cases with wilms' tumor and 25 cases with medulloblastomas in children by SABC immuohistochemical methods. RESULTS: 7(15.2%) cases with wilms' tumors were Pgp positive while 11( 44.0%) cases with medulloblastomas were Pgp positive. Statistical analysis revealed that expression of Pgp was significantly correlated with chemotherapy and NWTS Ⅱ classification of nephroblastoma( P <0.05), but there was no correlationship between expression of Pgp and NWTS Ⅲ clinical pathological stages of nephroblastomsas ( P >0.05). There was not correlationship between the expression of Pgp and clinical pathological classification of medulloblastomas ( P >0.05). CONCLUSION: Expression of Pgp,which could be induced and promoted by chemotherapy, may be an important parameter in the evaluation of malignance and prognosis of wilms' tumor. There was no correlationship between the expression of Pgp and clinical pathological classification of medulloblastomas.

关 键 词：肾母细胞瘤 髓母细胞瘤 P-糖蛋白 多药耐药 

分 类 号：R737.11[医药卫生—肿瘤]