中国人群恶性淋巴瘤发病危险因素的Meta分析  

Meta-analysis of case-control studies on risk factors of malignant lymphoma in China

作　　者：王琳[1] 谢贤和[1] 陈岩菊[1] 刘华[1] 王蔚[1] 麦泽锋[1] 邢雪花[1] 王海霞[1] 

机构地区：[1]海南省人民医院肿瘤内科,海南海口570311

出　　处：《实用肿瘤杂志》2010年第4期477-480,共4页Journal of Practical Oncology

摘　　要：目的探讨中国人群恶性淋巴瘤发病的主要危险因素。方法收集1994～2008年间国内关于恶性淋巴瘤危险因素的病例对照研究文献,并利用Meta分析方法进行综合分析。结果各影响因素与恶性淋巴瘤关系的合并OR值及95%CI分别为:吸烟1.32(1.03～1.70);家族肿瘤史2.75(1.21～6.26);乙型肝炎病毒感染1.59(1.06～2.37);接触有害化学物质2.29(1.06～4.90);手术史0.65(0.45～0.93);经济状况0.61(0.38～0.99)。结论吸烟、乙肝病毒感染、接触有害化学物质、家族肿瘤史是影响恶性淋巴瘤发生的危险因素,而经济状况好、手术史是恶性淋巴瘤的保护因素。Objective To investigate the risk factors related to the incidence of malignant lymphoma in China.Methods Published case-control studies on risk factors of malignant lymphoma from 1994 to 2008 in China were collected,and processed by means of Meta-analysis.Results A total of 493 cases and 665 controls from 4 studies were included.The pooled odds radio（OR） and 95%CI were：cigarette smoking OR=1.32（1.03～1.70）;family history of cancer OR=2.75（1.21～6.26）;hepatitis B infection OR=1.59（1.06～2.37）;exposure to harmful chemicals OR=2.29（1.06～4.90）;history of surgery OR=0.65（0.45～0.93）;higher socioeconomic level OR=0.61（0.38～0.99）.Conclusion Factors that might increase the risk of malignant lymphomas include cigarette smoking,family history of cancer,hepatitis B infection,exposure to harmful chemical materials,while history of surgery and higher socioeconomic level are the protective factors.

关 键 词：淋巴瘤/流行病学 吸烟 病例对照研究 危险因素 META分析 中国 回顾性分析 

分 类 号：R733.1[医药卫生—肿瘤]