加巴喷丁预防慢性偏头痛发作随机对比研究  

Randomized trial of Gabapentin on the Prevention of Chronic Migraine

作　　者：赵武伟[1] 何晓军[1] 雷文婧[1] 

机构地区：[1]解放军第81医院神经内科,江苏南京210002

出　　处：《慢性病学杂志》2010年第8期818-820,共3页Chronic Pathematology Journal

摘　　要：目的评价加巴喷丁对慢性偏头痛发作预防的有效性和安全性。方法共入组顽固性偏头痛病例60例。其中加巴喷丁组、吲哚美辛组治疗各30例。治疗前2组的一般资料、临床评价和实验室指标无统计学差异。结果治疗第1周,加巴喷丁组和吲哚美辛组头痛消失率分别为(76±5)%和(42±6)%(P<0.01);加巴喷丁组头痛缓解率(13±3)%,吲哚美辛组头痛缓解率(8±2)%(P>0.05),治疗第三周加巴喷丁组和吲哚美辛组头痛消失率分别为(89±6)%和(50±7)%(P<0.01);加巴喷丁组头痛缓解率(10±2)%和(12±3)%(P>0.05),加巴喷丁治疗中,有2例患者出现头晕,失眠,无肝、肾功能等影响。结论加巴喷丁治疗慢性阵发性偏侧头痛安全性好,可以作为预防控制慢性偏侧头痛的有效药物。Objective To assess the efficacy and safety of gabapentin on the prevention of chronic migraine.Methods 60 cases with chronic migraine were randomized divided into two groups.Group A was treated by gabapentin,group B was treated by indomethacin.Results After 1 week treatment,headaches disappeared rate was （76±5）% in group A and （42±6）% in group B （P0.01）;Headache response rate was （13±3）% in group A and （8±2）% in group B （P0.05）.After 3-week treatment,headaches disappeared rate was （89±6）% in group A and （50±7）% in group B （P0.01）;Headache response rate was （10±2）% in group A and （12±3）% in group B （P0.05）.2 patients had dizziness,insomnia in group A.Conclusion Gabapentin is safe and effective on the prevention of chronic migraine.

关 键 词：胺类/治疗应用 环己酸类/治疗应用 γ氨基丁酸/治疗应用 偏头痛/治疗 

分 类 号：R747.2[医药卫生—神经病学与精神病学]