腮腺硬化性多囊性腺病临床病理分析  

Sclerosing polycystic adenosis of salivary gland:one case report and review of literature

作　　者：李正金[1] 田林波[1] 赵立仙[1] 毕磊[1] 潘云[1] 

机构地区：[1]大理学院附属医院病理科,云南大理671000

出　　处：《海南医学》2010年第15期99-100,93,共3页Hainan Medical Journal

摘　　要：目的探讨腮腺硬化性多囊性腺病的临床病理特征和鉴别诊断。方法报道1例腮腺硬化性多囊性腺病的临床资料、HE染色和免疫组化染色结果,结合文献讨论。结果镜下见病变以大量增生胶原纤维为背景,其间分布不规则增生的导管和腺泡成分,呈模糊的小叶状结构,部分导管扩张呈囊状,结构类似乳腺纤维囊性病。部分扩张的导管上皮呈大汗腺样化生,部分上皮细胞呈合体细胞样,其胞质内含丰富、粗大的强嗜伊红颗粒,部分上皮呈泡沫细胞样,局部见平滑肌增生成结节状,间质中散在淋巴细胞浸润。结论腮腺硬化性多囊性腺病是一种罕见疾病,镜下病变复杂多样,需与慢性硬化性涎腺炎、多形性低度恶性腺癌、腺泡细胞癌、腺样囊性癌、黏液表皮样癌等鉴别。Objective To investigate clinical pathological feature and differential diagnosis of sclerosing polycystie adenosis of salivary gland. Methods One case of sclerosing polyeystie adenosis was report. The clinical data, pathological and immunohistochemical features and differential diagnosis of this disease were reviewed and discussed with the relevant literature. Results The patient was a 38 - year - old man, presenting with a painless left parotid swelling. Histologically, it was comparable to fibrocystic mastopathy and characterized by distinct hyalinized, centrally accentuated sclerosing coUageneous tissue with inclusion of cystically ectatic ducts, forming a vaguely lobular pattern. The dilated ducts frequently showed apocrine like mctaplasia and epithelial hyperplasia. Focally, acinar elements contained abundant large, intensely eosinophilic intracytop lasmic granules believed to rep resent altered zymogen granules. Some of other ductal epithelial cells showed foamy cell looking. Conclusion Sclerosing polycystic adenosis of salivary gland is rare disease. Differential diagnoses included chronic sclerosing sialadenitis of salivary gland, polymorphous low grade adenocarcinoma, acinic cell carcinoma, adenoid cystic carcinoma, mucoc- pidermoid carcinoma and so on.

关 键 词：腮腺肿瘤 腮腺硬化性多囊性腺病 诊断 鉴别 

分 类 号：R739.81[医药卫生—肿瘤]