肺硬化性血管瘤5例报道及文献复习  

5 cases of pulmonary sclerosing hemangioma and literature review

作　　者：张晓野[1] 陈霞恩[1] 赵守华[2] 窦恒利[3] 

机构地区：[1]山东中医药大学第二附属医院病理科,山东济南250001 [2]滕州市中心医院胸外科,山东腾州277500 [3]济南市第四人民医院胸外科

出　　处：《临床肺科杂志》2010年第9期1226-1228,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的分析肺硬化性血管瘤(sclerosing hemangioma of lung,SHL)组织成分及免疫组织化学表型,探讨其病理形态学特征、免疫组化在诊断中的价值。方法用免疫组化SP法对5例SHL组织标本的CK、CEA、EMA、CD34、SMA、MC、Vim、NSE、CgA进行标记,观察其表达情况。结果 SHL主要表现为乳头区、实性细胞区、血管瘤样区及硬化区等四种结构,乳头、实性区裂隙及血管瘤样区表面衬覆有立方状上皮细胞,乳头间隙及实性细胞区为圆形多角形胞质浅染的细胞。免疫组化显示乳头、实性区裂隙及血管瘤样区表面衬覆细胞阳性表达CK、CEA、EMA,圆形或多角形细胞阳性表达Vim和CgA,NSE和EMA在圆形或多角形细胞灶性表达阳性,CD34仅在肿瘤组织中的血管内皮细胞呈阳性表达,MC和SMA在两种细胞均为阴性表达。结论 SHL的组织成分包括表面的立方状上皮细胞、圆形多角形胞质浅染的细胞、肺泡腔内出血和硬化性变化,四种组织结构至少存在三种,免疫组化对SHL的诊断有帮助。Objective To analyze composition and immunohistochemistry of SHL,and to investigate pathological characteristics and diagnostic value of immunohistochemistry of SHL.Methods Using immunohistochemisty methods,the expression of CK,Vim,NSE,CEA,EMA,CD34,SMA,MC,and Vim,NSE,CgA were observed in 5 cases of SHL.Results SHL demonstrated the histologic patterns with variable proportions of solid,papillary,hemangioma-like and sclerotic pattern.Cuboidal or columnar cells covered the papillary and cleft-slide spaces in solid areas whereas solid areas and stalk of papillary projections were composed of uniform,round or polygonal pale cells.The cuboidal or columnar cells were positive for CK,CEA,EMA.The round or polygonal pale cells expressed vimentin and CGA,with some of them showing positive for NSE and EMA.Only endothelial cells of blood vessel were positive for CD34.Both cuboidal or columnar and round or polygonal pale cells displayed negative immunohistochemical result to MC and SMA.Conclusion The SHL consists of cuboidal cells and polygonal pale cells and hemangioma-like areas and sclerotic areas.The presence of three patterns is necessary.The immunohistochemistry is helpful to diagnosis.

关 键 词：肺硬化性血管瘤 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]