正常老年人与阿尔茨海默病患者尿甲醛浓度的研究  

Research on urine formaldehyde concentration in Alzheimer's disease elderly and normal elderly

作　　者：王维山[1] 郝智慧[1] 张力[1] 李文杰[1] 李沫[1] 张金玲[2] 赫荣乔[2] 

机构地区：[1]北京老年医院精神心理科,100095 [2]中国科学院生物物理研究所脑与认知科学国家重点实验室

出　　处：《中华老年心脑血管病杂志》2010年第8期721-722,共2页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨正常老年人与阿尔茨海默病(Alzheimer’s disease,AD)患者的尿甲醛浓度。方法随机选取年龄≥65岁的正常老年人(正常组)和确诊为AD患者-(AD组)各30例,对2组患者的尿甲醛浓度进行测定分析。结果 AD组患者尿甲醛浓度(0.26±0.22)mmol/L,显著高于正常组(0.04±0.02)mmol/L,差异有统计学意义(t=-5.269,P<0.01)。结论机体内甲醛浓度超标可能是老年人发生AD的一个原因。Objective To compare the urine formaldehyde concentration of normal elderly and Alzheimer’s disease elderly.Methods Thirty normal elderly as normal group and 30 Alzheimer’s disease elderly as patient group were selected at random.Two groups’ urine formaldehyde concentrations were measured and analyzed.Results The urine formaldehyde concentrations were significantly different between Alzheimer’s disease elderly and normal elderly（t=-5.269,P〈0.01）.The urine formaldehyde concentration of patients group（0.26±0.22） was significantly higher than that of normal group（0.04±0.02）.Conclusion The level of endogenous formaldehyde higher than normal may be one of the pathogenic factors for sporadic Alzheimer’s disease.

关 键 词：阿尔茨海默病 甲醛 尿 神经元 色谱法 高压液相 

分 类 号：R749.16[医药卫生—神经病学与精神病学]