Parietal cortex contributions to information granules following memory consolidation  

作　　者：WANG XiuZhen ZHONG Ning LU ShengFu LI KunCheng LANG ShuLei 

机构地区：[1]Learning & Cognition Laboratory, International WIC Institute, Beijing University of Technology, Beijing 100022, China [2]Harbin Normal University, Harbin 150301, China [3]Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi, Japan [4]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

出　　处：《Chinese Science Bulletin》2010年第24期2671-2676,共6页

基　　金：supported by the National Natural Science Foundation of China(60673015,60775039 and 08BTQ024);the Grant-in-aid for Scientific Research(18300053)from the Japanese Ministry of Education,Culture,Sports,Science and Technology

摘　　要：Previous studies have focused on changes in cerebral cortex activity accompanying memory formation and consolidation.Although the role of the parietal cortex in memory retrieval is well established,it is not well understood how parietal cortex memory consolidation for mathematical rules is related to granularity of stored information(i.e.,degree of detail or precision).Changes in parietal cortex activity associated with memory consolidation were analyzed using the Ebbinghaus paradigm and functional magnetic resonance imaging(fMRI).Over the course of 1 week,participants learned Boolean arithmetic tasks involving stimulus-response mapping rules containing either low-or high-granularity information.FMRI images were collected on day 1(i.e., low-granularity condition)and day 7(i.e.,high-granularity condition).The present data suggested that with practice,stored information was converted from a low-granularity to a high-granularity form.By following rule learning,it was hypothesized that the process of consolidation would involve an increased degree of rule representation granularity.Evidence for this process was reflected in parietal cortex activity.This finding was consistent with the hypothesis that mnemonic reconstruction in the parietal cortex is required for memory consolidation,and results suggested that information granules are formed during memory consolidation.The present results could increase the understanding of the relationship between memory consolidation and information granularity.Previous studies have focused on changes in cerebral cortex activity accompanying memory formation and consolidation. Although the role of the parietal cortex in memory retrieval is well established, it is not well understood how parietal cortex memory consolidation for mathematical rules is related to granularity of stored information （i.e., degree of detail or precision）. Changes in parietal cortex activity associated with memory consolidation were analyzed using the Ebbinghaus paradigm and functional magnetic resonance imaging （fMRI）. Over the course of 1 week, participants learned Boolean arithmetic tasks involving stimulus-response mapping rules containing either lowor high-granularity information. FMRI images were collected on day 1 （i.e., low-granularity condition） and day 7 （i.e., high-granularity condition）. The present data suggested that with practice, stored in- formation was converted from a low-granularity to a high-granularity form. By following rule learning, it was hypothesized that the process of consolidation would involve an increased degree of rule representation granularity. Evidence for this process was reflected in parietal cortex activity. This finding was consistent with the hypothesis that mnemonic reconstruction in the parietal cortex is required for memory consolidation, and results suggested that information granules are formed during memory consolidation. The present results could increase the understanding of the relationship between memory consolidation and information granularity.

关 键 词：信息颗粒 大脑皮质 记忆 功能性磁共振成像 信息粒度 功能磁共振成像 大肠杆菌 fMRI 

分 类 号：R741[医药卫生—神经病学与精神病学]