精神分裂症与表皮生长因子4(ERBB4)基因多态性的关联研究  

Association Study of the ERBB4 Polymorphisms with Schizophrenia

作　　者：卢天兰[1] 赵振国[1] 阮燕燕[1] 岳伟华[1] 张岱[1] 

机构地区：[1]北京大学精神卫生研究所,卫生部精神卫生学重点实验室,北京100191

出　　处：《现代生物医学进展》2010年第14期2601-2604,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(30870896);国家高技术研究发展(863)计划(2008AA02Z401)

摘　　要：目的:探讨表皮生长因子4(ERBB4)基因多态性与精神分裂症及发病年龄的遗传关联。方法:应用病例对照遗传关联研究设计,采用TaqMan技术检测方法,检测并分析768例精神分裂症患者和813例年龄、性别、民族匹配的正常对照者中ERBB4基因的5个单核苷酸多态性(SNP)位点与精神分裂症及发病年龄的关联。结果:ERBB4基因的4个SNPs多态性位点与精神分裂症显著关联(rs1851185,C>T,x2=4.37,P=0.036;rs6435689,C>T,x2=6.772,P=0.009;rs11887531,C>T,x2=6.876,P=0.008;rs12468336,C>T,χ2=6.443,P=0.011)与精神分裂症关联,由rs11887531-rs12468336-rs16847823组成的单体型CCC与精神分裂症关联(x2=7.519,P=0.006),并与精神分裂症发病年龄关联(CCC携带者20.17±3.87岁,非CCC携带者23.01±4.85岁,t=2.98,P=0.032)。结论:ERBB4基因多态性可能与精神分裂症发病机制关联。Objective：To investigate the effect of the ERBB4 polymorphisms on schizophrenia.Methods：Five single nucleotide polymorphisms （SNPs） of ERBB4 gene in 768 schizophrenic patients and 813 healthy persons were analyzed by the TaqMan genotyping methods.Results：Four SNPs were found to be associated with schizophrenia （rs1851185, CT,x2=4.37, P=0.036; rs6435689, CT, x2=6.772, P=0.009; rs11887531, CT,x2=6.876, P=0.008;rs12468336, CT, x2=6.443, P=0.011）.Haplotypes consisted by rs11887531-rs12468336-rs16847823 were also associated with schizophrenia （CCC or TTT, x2=7.519, P=0.006）.The age-at-onset of patients carrying the haplotype CCC showed younger than that of the the Non-CCC carriers （20.17±3.87 yr vs.23.01±4.85 yr, t=2.98, P=0.032）.Conclusions：The ERBB4 polymorphisms might play an important role in the susceptibility to schizophrenia.

关 键 词：精神分裂症 ERBB4基因 关联研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学]