肝硬化合并自发性细菌性腹膜炎临床耐药分析  

Clinical and Drug Resistance Analysis of Patients with Cirrhosis complicating Spontaneous Bacterial Peritonitis

作　　者：陈楚雄[1] 曾美仪[1] 伍俊妍[1] 陈为宪[2] 王连源[2] 

机构地区：[1]中山大学附属第二医院药学部,510120 [2]中山大学附属第二医院消化内科,510120

出　　处：《岭南急诊医学杂志》2010年第4期290-291,306,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:了解肝硬化合并自发性细菌性腹膜炎(SBP)患者的病原菌及其耐药情况。方法:回顾性分析肝硬化合并SBP细菌培养阳性者82例的临床资料。结果:肝硬化患者合并SBP的病原菌中革兰阴性菌占67%,革兰阳性菌占29%,白色假丝酵母菌占4%;第三代头孢菌素与喹诺酮类药物的耐药率明显增加,而临床上使用较少的氨基糖苷类抗菌药物对大肠埃希菌的耐药率较低;美罗培南、亚胺培南、替考拉宁和万古霉素的耐药率低。结论:尽可能对肝硬化合并腹水患者进行腹腔穿刺检查,根据药敏试验结果合理选择抗菌药物。Objective：To know the pathogens of spontaneous bacterial peritonitis （SBP） in cirrhosis patients and their drug resistance. Methods： The clinical data of 82 patients with liver cirrhosis complicating SBP positive bacterial culture were analyzed. Results：The pathogens of Gram-negative bacteria, Gram-positive bacteria and Enterococeus faeealis accounted for 67%,29% and 4% respectively. The resistance rates to the third generation cephalosporins and quinolones were increased significantly, while the less used aminoglycosides clinically had lower resistance rates for E. coli. Meropenem, imipenem, teicoplanin and vaneomycin were all with low resistance rate.Conclusions ： The peritoneocentesis must be used in liver cirrhosis patients with ascites as far as possible, must be reasonably selected according to antimicrobial susceptibility test of antimicrobial agents.

关 键 词：肝硬化 自发性细菌性腹膜炎 

分 类 号：R575.2[医药卫生—消化系统]