五味子醇提物对小鼠老化模型脑神经递质的影响  

Effect of Schisandra Chinensis baill distilled by ethanol on acetylcholinesterase,neurotransmitter in aging mice model induced by D-galactose

作　　者：苗明三[1] 马霄[1] 张广伟[1] 王力男[1] 

机构地区：[1]河南中医学院,河南郑州450008

出　　处：《中国老年学杂志》2010年第15期2162-2163,共2页Chinese Journal of Gerontology

基　　金：河南省高等学校创新人才培养工程(2004-23)

摘　　要：目的探讨五味子醇提物对小鼠脑老化模型脑乙酰胆碱酯酶(AChE)、单胺类神经递质的影响。方法小鼠颈背部皮下连续40d注射5%D-半乳糖造脑老化模型,另设空白对照组,皮下注射生理盐水。从第11天分别灌服相应药物,1次/d。于最后1次给药后2h,小鼠断头取脑,测脑匀浆AChE活性和单胺类神经递质含量。结果与模型组相比,大剂量组可显著降低模型小鼠脑AchE活力,显著提高脑去甲肾上腺素(NA)、多巴胺(DA)水平,明显提高5-羟色胺(5-HT)水平。结论五味子醇提部位可调节中枢神经递质的合成,有利于学习记忆,有抗脑老化作用。Objective To observe the effect of Schisandra Chinensis Baill distilled by ethanol on acetylcholinesterase and neurotransmitter in aged mice model induced by D-galactose.Methods 5% D-galactose saline solution was injected into neck back subcutaneous tissue of mice to make the aged mice model for 40 days.From the 11th day,mice were filled with big,small dosage of Schisandra Chinensis Baill distilled by ethanol,Naokangling troche and the same dosage of saline solution everyday respectively.The blank control group was given hypertonic saline.Experiment was started on 2 h after giving D-galactose and Schisandra Chinensis Baill distilled by ethanol in the last time.The activity of acetylcholinesterase （AchE） and the level of monoamine neurotransmitter in brain tissue were detected.Results Compared with model group,big dosage of Schisandra Chinensis Baill distilled by ethanol notably reduced the activity of AChE of mice,increased the level of nonadrenaline and dopamine,and increased the level of 5-hydroxytryptamine （5-HT） in the brain.Conclusions Schisandra Chinensis Baill distilled by ethanol could effectively adjust and improve the central neurotransmitter synthesis and be beneficial to learning and memory improvement and anti-brain aging.

关 键 词：五味子醇提物 D-半乳糖 脑老化 神经递质 

分 类 号：R749.16[医药卫生—神经病学与精神病学]