沙立度胺抗肿瘤作用机制与临床应用研究进展  

Progress in the research of antitumor mechanism and clinical application of thalidomide

作　　者：施有琴[1,2] 王荣[1,2] 谢华[2] 贾正平[1,2] 郭志强[2] 郭立方[1] 

机构地区：[1]兰州大学药学院,甘肃兰州730000 [2]兰州军区兰州总医院国家药物临床药理试验基地,甘肃兰州730050

出　　处：《中国药理学通报》2010年第8期993-996,共4页Chinese Pharmacological Bulletin

基　　金：国家科技部重大项目(No2008ZXJ-09014-010)

摘　　要：沙立度胺最初作为一种镇静止吐剂用于治疗妊娠呕吐,但由于其严重的致畸作用被禁用。近年来研究发现沙立度胺具有抑制新生血管形成及免疫调节等活性被广泛用于多种恶性肿瘤治疗的研究,并在多发性骨髓瘤(MM)及多种实体肿瘤的治疗中显示了良好的疗效。该文就沙立度胺抗肿瘤的作用机制及抗肿瘤临床应用研究进展做一综述。Thalidomide was initially used to treat vomiting of pregnancy as a sedative and antiemetic,but then was prohibited for its severe side effects of teratogenesis. In recent years,due to its property of antiangiogenesis and immunomodulation effects,it has been widely used in the therapy of many malignant tumors and accordingly has produced satisfactory effects for multiple myeloma（ MM） and many solid tumors. This article reviews thalidomide in both its mechanism of anti-tumor action and its clinical application progress.

关 键 词：沙立度胺 抗肿瘤 作用机制 抗血管新生 免疫调节 临床研究 

分 类 号：R-05[医药卫生] R971.3