药物诱发尖端扭转性室性心动过速筛选模型的发展与应用  

Development and application of models for screening torsade de pointes induced by drugs

作　　者：柳强妮[1] 曾繁典[1] 

机构地区：[1]华中科技大学同济医学院药理系,湖北武汉430030

出　　处：《中国药理学通报》2010年第7期841-843,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题(No30572346)

摘　　要：近年来,许多药物由于存在引发尖端扭转性室性心动过速(TdP)和猝死的潜在风险而从市场上撤出。鉴于此,一系列药物引发TdP的筛选模型应运而生,用于药物开发早期检测药物的致心律失常特性,以加强药品上市前风险管理。该文简要综述一系列临床前筛选模型的原理及特点,为药物开发进行临床前安全性评估提供参考。In recent years,a large number of drugs have been withdrawn from the market because of torsade de pointes（TdP） and sudden cardiac death,which pose great risks in drug application.Therefore,the different models have been developed to detect TdP liability during the early stage of drug development.In this paper,the principles and characteristics of these screening models are reviewed to give props for preclinical safety assessment.

关 键 词：药物致心律失常 尖端扭转性室性心动过速 在体动物模型 体外模型 HERG 胞内钙离子 

分 类 号：R-05[医药卫生] R541.7