胰腺星状细胞在胰腺纤维化中的作用  

Role of Pancreatic Stellate Cells in Pancreatic Fibrosis

作　　者：郑振江[1] 向光明[1] 刘续宝[1] 

机构地区：[1]四川大学华西医院肝胆胰外科,成都610041

出　　处：《中国普外基础与临床杂志》2010年第8期876-879,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的介绍胰腺星状细胞在胰腺纤维化中的作用及抗胰腺纤维化研究进展。方法复习相关文献资料并作综述。结果胰腺星状细胞的活化与胰腺纤维化密切相关,抑制胰腺星状细胞活化可为临床治疗慢性胰腺炎提供新的途径。结论胰腺星状细胞是胰腺纤维化发病的关键环节,并逐渐成为抗胰腺纤维化及治疗慢性胰腺炎的重要靶标。Objective To introduce the role of pancreatic stellate cells in pancreatic fibrosis and the progress in treatment of pancreatic fibrosis. Methods Relevant literatures were collected and reviewed. Results Pancreatic stellate cells activation was closely related to pancreatic fibrosis. Inhibition of pancreatic stellate cells activation could provide a new approach in clinical treatment of chronic pancreatitis. Conclusion Pancreatic stellate cells are the key to pancreatic fibrosis,which are becoming the target for anti-fibrosis of the pancreas and treatment of chronic pancreatitis.

关 键 词：胰腺星状细胞 胰腺纤维化 慢性胰腺炎 治疗 

分 类 号：R576[医药卫生—消化系统]