STAT3与磷酸化STAT3在非小细胞肺癌中的表达及临床意义  

Expression and clinical significance of P-STAT3 and STAT3 in non-small cell lung cancer

作　　者：周爱民[1] 

机构地区：[1]安徽中医药高等专科学校医疗系,芜湖241000

出　　处：《安徽医学》2010年第8期871-873,共3页Anhui Medical Journal

基　　金：安徽中医药高专自然科学研究一般项目(ZRKX0808)

摘　　要：目的检测STAT3及磷酸化STAT3(P-STAT3)在非小细胞肺癌组织和正常肺组织中的表达并探讨临床意义。方法应用免疫组化ABC法检测49例手术切除的非小细胞肺癌组织及10例正常肺组织中的P-STAT3和STAT3的表达。结果非小细胞肺癌组织中STAT3和P-STAT3的阳性率分别为65.3%、46.9%,均显著高于其在正常肺组织中的表达;两者的阳性表达与肿瘤组织的临床分期及是否有淋巴结转移相关。结论 STAT3在非小细胞肺癌组织中的异常活化与肺癌的发生发展密切相关,抑制STAT3及其信号传导通路有望成为治疗非小细胞肺癌的新的靶点。Objective To investigate the expression of STAT3 and P-STAT3 in human normal lung tissues and non-small cell lung cancer tissues（NSCLC） and explore their clinical significance.Methods Immunohistochemical ABC method was used to examine the expression of STAT3 and P-STAT3 in 49 cases of NSCLC and 10 cases of paracancerous normal lung tissues.Results The positive staining rate of STAT3 and P-STAT3 protein in NSCLC tissues were 65.3% and 46.9 %,respectively.There were significant higher than normal lung tissues.The expression of STAT3 and P-STAT3 was correlated to clinical stages and lymph node metastasis.Conclusion Abnormal activation of STAT3 in non-small cell lung cancer is closely associated with progression of non-small cell lung cancer tissues and suppression of STAT3 as well as signal transduction pathway can be a new target for treatment of non-small cell lung cancer.

关 键 词：STAT3蛋白 P-STAT3蛋白 肺肿瘤 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]