对Lennox-Gastaut综合征的新认识  

The new perspective on Lennox-Gastaut syndrome

作　　者：王静[1] 邹丽萍[1] 

机构地区：[1]中国人民解放军总医院儿童医学中心,北京100853

出　　处：《临床儿科杂志》2010年第8期788-792,共5页Journal of Clinical Pediatrics

基　　金：国家自然科学基金资助项目(No.30801249;No.30770747);卫生行业科研专项基金资助项目(No.200802074);北京市自然基金资助项目(No.7042024;No.7081002)

摘　　要：Lennox-Gastaut综合征(LGS)是一种在儿童期发病的严重癫疒间性脑病。临床表现为多种癫疒间发作形式、精神发育迟缓、脑电图弥漫的棘慢复合波。早期诊断困难,传统抗癫疒间药物疗效不佳。近年来多种新抗癫疒间药物用于LGS治疗,治疗观念及治疗效果评价也有所改变。文章就LGS诊断、治疗指南,以及一些新的认识进行综述。Lennox-Gastaut syndrome（LGS） is one of the most severe epileptic encephalopathies of childhood onset.The clinical manifestations include many types of seizure,mental retardation,and slow spike-wave complexes on electroencephalographic（EEG） recordings.Early diagnosis is often difficult;treatment with conventional antiepileptic drugs has poor response.In recent years,many new antiepileptic drugs were used,therapy concepts and assessments have changed.The main issues on the guidelines as well as new perspective on LGS diagnosis and therapy will be discussed in this review.

关 键 词：LENNOX-GASTAUT综合征 诊断 脑电图 治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学]