酶工程技术在中药活性成分获得中的研究进展  

Progress in Preparation by Enzyme Engineering Technology for Highly Active Substances from Traditional Chinese Medicines

作　　者：许明淑[1] 郭兰萍[2] 赵无恙[1] 杨光[2] 

机构地区：[1]山东大学威海分校海洋学院,山东威海264209 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2010年第10期195-198,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划(2006CB504700);国家中医药管理局行业专项(200707014)

摘　　要：目的:探讨酶工程技术应用于中药研究的现状及问题。方法:查阅酶工程技术提取中药活性成分的文献,并对其进行归纳、分析和总结。结果:酶工程在中药破壁提取,中药有效成分的定向提取,酶转化获高活性成分已在多种中药研究中展开,提示通过酶工程技术获得高活性物质是经济便利的中药提取方法。结论:为酶转化中药活性物质研究的进一步发展提出参考依据。Objective：To summarize the recent development on the utilization of enzyme engineering technology in obtaining active ingredients from traditional Chinese medicines. Method：The published articles on extracting active ingredients from traditional Chinese medicines by enzyme engineering technology were reviewed and analyzed. Result：The enzymatic lysis of cell wall for the extraction of substances,the directional extraction of active substances,and the enzymatic transformation of substances with low or no activity to highly active substances have been carried out with various traditional Chinese medicines,indicating that the enzymatic method is economically efficient and convenient in the production of highly active substances from traditional Chinese medicines. Conclusion：This study will provide a reference for the further research and development of enzymatic extraction and transformation of active substances from traditional Chinese medicines.

关 键 词：酶转化 高活性物质 中药提取 

分 类 号：R283.6[医药卫生—中药学]