Synthesis and Complexation Properties of Novel Chiral Calix[4]-1,3-aza-crown and Calix[4]arene Hydrazone Derivative  

作　　者：YANG Fa-fu HUANG Zhi-sheng GUO Hong-yu HONG Bi-qiong ZHANG Xiao-yi 

机构地区：[1]College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, P R. China [2]Fujian Key Laboratory of Polymer Materials, Fuzhou 350007, P. R. China

出　　处：《Chemical Research in Chinese Universities》2010年第4期546-549,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.20402002);Natural Science Foundation of Fujian Province,China(No.2009J01019)

摘　　要：Refluxing calix[4]-1,3-substituted benzaldehyde derivative（4） with glycine hydrazide derivative, we obtained a novel calix[4]arene hydrazone derivative（5） via ＂1＋2＂ condensation in a yield of 78%. In the reaction of compound 4 with L-leucine hydrazide derivative at room temperature, lariat calix[4]-1,3-aza-crown（6） with chiral amino acid group as branched chain was synthesized via ＂1＋ 1＂ addition in a yield of 70%. The preliminary extraction experiments suggested that hosting compounds 5 and 6 possessed good complexation abilities for a-amino acids.Refluxing calix[4]-1,3-substituted benzaldehyde derivative（4） with glycine hydrazide derivative, we obtained a novel calix[4]arene hydrazone derivative（5） via ＂1＋2＂ condensation in a yield of 78%. In the reaction of compound 4 with L-leucine hydrazide derivative at room temperature, lariat calix[4]-1,3-aza-crown（6） with chiral amino acid group as branched chain was synthesized via ＂1＋ 1＂ addition in a yield of 70%. The preliminary extraction experiments suggested that hosting compounds 5 and 6 possessed good complexation abilities for a-amino acids.

关 键 词：CALIX[4]CROWN CHIRAL Amino acid Hydrazone Extraction 

分 类 号：TQ577.36[化学工程—精细化工] O625.1[理学—有机化学]