随意运动控制的全脑功能磁共振成像研究  

Whole-brain Functional Magnetic Resonance Imaging Analysis of Motor Control in Human Brain

作　　者：侯莉娟[1] 周立明[2] 宋争[2] 于勇[1] 王君[2] 

机构地区：[1]北京师范大学体育与运动学院,北京100875 [2]北京师范大学认知神经科学与学习国家重点实验室,北京100875

出　　处：《体育科学》2010年第8期62-68,共7页China Sport Science

基　　金：国家自然科学基金资助项目(30800267);教育部留学回国人员科研启动基金资助项目

摘　　要：目的:利用全脑功能磁共振成像(fMRI)技术,对参与上下肢左右侧关节随意运动的大脑皮层控制区及皮层下基底神经节核团进行研究,探讨不同运动控制区在随意运动中的调控机制。方法:采用Siemens公司MAGNETOM Trio3.0T磁共振成像系统,对7名健康右利手志愿者进行左右侧踝关节以及利手、非利手随意运动时的全脑fMRI扫描。数据经过头动校正、空间标准化,高斯平滑等预处理后,通过相关分析分别获得左右侧踝关节、利手以及非利手随意运动的脑激活图,采用SPM软件对参与随意运动的脑区进行解剖定位并对其调控机制进行分析讨论。结果:利手运动主要激活对侧初级运动区(M1),双侧辅助运动区(SMA)和双侧小脑,各激活区域中心点激活范围为3.15～6.68。非利手运动主要激活双侧小脑、SMA以及苍白球、纹状体和丘脑等基底神经核团,各激活区域中心点激活范围为3.30～7.19,参与非利手运动控制的脑区激活量是利手的2.31倍。左右侧踝关节随意运动主要激活对侧M1、双侧SMA以及小脑,中心点激活量范围为3.15～7.41。结论:上下肢的随意运动主要依赖于大脑皮质和小脑等结构,同时基底神经节也是参与其调控的重要神经核团。Objective：To identify the neural correlates of voluntary movements of hand and ankle by using the whole brain functional magnetic resonance imaging technique.Methods：Seven right handed healthy volunteers were scanned at MAGNETOM Trio 3.0 Tesla magnetic resonance imaging scanner （Siemens） while performing the visually instructive movement tasks with their right and left hands and ankles.Image datasets were spatially normalized according to the standard coordinate,and spatially smoothed with isotopic Guassian Kernel.Statistical parametric maps （activation maps） for right and left hands and ankles were generated respectively by cross-correlation analysis.Results：Dominant hand movement mainly activated contra-lateral primary motor cortex （M1）,bilateral supplementary motor area （SMA） and cerebellum,the total activation of the central spots is 3.15~6.68.Non-dominant hand movement mainly activated bilateral SMA,cerebellum and basal ganglion,the total activation of the central spots is 3.30~7.19,and it is 2.31 times of the dominant hand.Bilateral ankle voluntary movements mainly activated bilateral M1,SMA and cerebellum,the total activation of the central spots is 3.15~7.41.Conclusion：A large set of structures in the cerebral cortex and cerebellum are involved in voluntary movements.At the same time,the basal ganglion is also the important regulation and control central nucleus during voluntary movement.

关 键 词：运动控制 磁共振成像 大脑 手 踝关节 

分 类 号：G804.5[文化科学—运动人体科学]