汕头地区近15年青年结直肠癌临床特征与预后分析  

An Analysis of Clinical Characteristics and Prognosis in Young Patients with Colorectal Cancer in Recent 15 Years in the Shantou Area, Guangdong Province

作　　者：吴俊东[1] 庄业忠[1] 林楚容[2] 黄文河[1] 黄棉生[1] 王伟峰[1] 许慕明[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院,广东汕头515031 [2]汕头市中心医院,广东汕头515031

出　　处：《中国肿瘤》2010年第8期545-548,共4页China Cancer

基　　金：汕头市重点科技计划项目(汕府科[2008]85号)

摘　　要：[目的]探讨汕头地区近15年青年结直肠癌的临床特点及预后情况。[方法]回顾汕头地区两家医院1993～2008年间收治的672例青年(≤40岁)结直肠癌资料。[结果]近15年青年结直肠癌收治率增加82.80%,但构成比却下降2.48%(P=0.03);发病中位年龄上升5岁;早期诊断率(≤3个月)提高11.09%,误诊率下降12.35%(P<0.05);结直肠癌中直肠癌比例从55.78%下降至45.32%(P<0.05);根治性手术及辅助放、化疗比例明显提高(P<0.05),Ⅲ期患者5年生存率显著提高(P<0.05);而男女比例、病理类型、TNM分期、结直肠癌肿右半结肠癌比例及3、5年总生存率差异无统计学意义(P>0.05)。[结论]近15年汕头地区青年结直肠癌的发病比例下降,发病年龄上升,直肠癌比例下降,早期诊断率上升,误诊率下降,Ⅲ期患者5年生存率显著提高,但总生存率并未明显提高。[Purpose] To investigate the clinical characteristics and prognosis in young patients with colorectal cancer in the past 15 years in the Shantou area. [Methods] Data of 672 young patients （age≤40） with colorectal cancer in two hospitals in the Shantou area from 1993 to 2008 were analyzed retrospectively. [Results] In the past 15 years, the rate of young colorectal cancer patients treated increased 82.80%, but the proportion decreased 2.48%（P=0.03）,the median age of disease increased 5 years, the early diagnosis rate （≤3 months） increased 11.09% and the misdiagnosis rate decreased 12.35%（P〈0.05）. The proportion of rectal cancer in colorectal cancer decreased from 55.78% to 45.32%（P〈0.05）.The proportion of radical operation and adjuvant radiotherapy as well as chemotherapy increased significantly（P〈0.05）. The 5-years survival rates of patients with stage Ⅲ improved significantly（P〈0.05）. However, the male to female ratio and pathological type as well as TNM stage were not significantly different, and the proportion of right hemicolon cancer in colorectal cancer and the 3-, 5-years overall survival rates were not significantly improved（P〈0.05）. [Conclusion] In recent 15 years, the proportion of colorectal cancer decreased in young patients in the Shantou area, with the median age increase, proportion of rectal cancer decrease, the early diagnosis rate increase and the misdiagnosis rate decrease, the 5-year survival rate of patients with stage Ⅲ improve, but the overall survival rate were not significantly improved.

关 键 词：结直肠癌 青年人 临床流行病学 预后 广东 

分 类 号：R735.3[医药卫生—肿瘤]