低剂量辐射诱导小鼠脾细胞转铁蛋白受体表达的适应性反应  

Adaptive response of TfR expression induced by low dose radiation in splenocytes of mice.

作　　者：罗灿[1] 苏旭[1] 付士波[1] 鞠桂芝[1] 

机构地区：[1]白求恩医科大学卫生部放射生物重点实验室

出　　处：《中国辐射卫生》1999年第2期68-69,共2页Chinese Journal of Radiological Health

摘　　要：本文采用直接免疫荧光流式细胞术方法，检测了低剂量Ｘ射线全身照射后２４ｈ，小鼠脾脏淋巴细胞转铁蛋白受体（ＴｆＲ）表达的变化及诱导ＴｆＲ表达的适应性反应。结果表明，７５ｍＧｙＸ射线全身照射可增强脾脏淋巴细胞ＴｆＲ的表达，并可明显减轻其后２Ｇｙ照射对小鼠脾脏淋巴细胞ＴｆＲ表达的抑制，诱导ＴｆＲ表达的适应性反应。说明ＴｆＲ可能在低剂量辐射诱导免疫适应性反应中发挥作用。Using direct immunoflurescence and flow cytometric analysis,Transferrin recepor (TfR) expression and adaprtive response were examined in lymphocytes in mouse spleens 24 hours after whole body irradiation (WBI)with low dose X-rays.The results showed that WBI with 75 mGy X-rays could enhance TfR expression in lymphocytes in mouse spleens,and could reduce the inhibition to TfR expression by 2Gy irradiation after given 75 mGy irradiation and induce adaptive response of TfR expression. It is demonstrated that TfRs may play a role in immune adaptive response induced by low dose radiation.

关 键 词：TFR 脾细胞 低剂量辐射 适应性反应 

分 类 号：R811.5[医药卫生—放射医学] R815[医药卫生—临床医学]