HP感染对胃癌组织中淋巴管密度的影响  

Effect of HP Infection on the Lymphatic Vessel Density of the Gastric Carcinoma

作　　者：季英兰[1] 张志广[2] 李熳[2] 闻淑军[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津医科大学第二医院消化内科,天津300211

出　　处：《中国慢性病预防与控制》2010年第4期383-384,共2页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨幽门螺杆菌(Hp)在胃癌淋巴转移中的作用。方法应用免疫组化方法检测80例胃癌标本中D2-40的表达情况并计数淋巴管密度(lymphatic vessel density,LVD),改良Giemsa染色法检测Hp。结果胃癌标本Hp阳性率为66.25%。有淋巴结转移胃癌标本LVD(15.11±7.30)高于无淋巴结转移标本LVD(10.67±3.80),差异有统计学意义(P<0.05)。Hp阳性胃癌标本LVD(16.33±6.89)高于Hp阴性胃癌标本LVD(9.10±3.10),差异有统计学意义(P<0.05)。胃癌标本中LVD在不同的性别、年龄、组织学分化程度、临床分期的差异无统计学意义。结论 Hp可能对胃癌的淋巴转移起促进作用。Objective To investigate the role of Helicobacter pylori in lymph node metastasis of gastric carcinoma. Methods Immunohistochemistry technique was used to detect the expression of D2-40 in 80 gastric carcinoma specimens and to count the lymphatic vessel density （LVD）, Hp infection was determined by improved Giemsa method. Results The infection rates of Hp in gastric carcinoma specimens were 66.25%. The LVD in the lymph node metastasis group （15.11 ±7.30）was higher than that in lymph node non-metastasis group （10.67±3.80）（P〈0.05）. The LVD in Hp positive group （16.33±6.89） was higher than that in Hp negative group （9.10±3.10）（P〈0.05）. There were no significant differences of the number of LVD in gastric carcinoma specimens between different sex, age, differentiation degree and clinical stage. Conclusion Hp infection may promote the lymph node metastasis in gastric carcinioma.

关 键 词：胃癌 免疫组织化学 幽门螺杆菌 淋巴管密度 

分 类 号：R73[医药卫生—肿瘤]