CA19-9和肝功能联合检测用于鉴别诊断胰腺癌和胰腺炎  

CA19-9 and Liver Function Analysis for Differential Diagnosis of Pancreatic Cancer and Pancreatitis

作　　者：刘改霞[1,2] 董矜[1] 向荣[2] 田亚平[1,2] 

机构地区：[1]解放军总医院生化科,北京100853 [2]南开大学医学院,天津300071

出　　处：《标记免疫分析与临床》2010年第4期223-226,共4页Labeled Immunoassays and Clinical Medicine

基　　金：国家科技支撑计划(2009BAI86B05)

摘　　要：探讨CA19-9及肝功能各生化指标水平在胰腺癌、急慢性胰腺炎患者血清中的变化规律,探索多指标联合检测用于鉴别诊断胰腺癌和胰腺炎的临床价值。采用电化学发光免疫法与生化比色法分别检测70例胰腺癌患者、43例急性胰腺炎患者、25例慢性胰腺炎患者及65名正常人血清中CA19-9和肝功能各生化指标的含量。结果显示,与对照组相比,胰腺癌组、急慢性胰腺炎组的ALB水平均显著降低(P<0.01),CA19-9、TBA、DBIL、AST、γ-GT及ALP水平均显著升高(P<0.01),TBIL及ALT水平的差异无显著意义(P>0.05)。胰腺癌组与急性胰腺炎组相比,CA19-9及ALB水平显著升高(P<0.01),γ-GT水平显著降低(P<0.05);与慢性胰腺炎组相比,仅有CA19-9水平显著升高(P<0.01)。两胰腺炎组比较,各指标的差异均无显著意义(P>0.05)。胰腺癌组内,CA19-9与肝功能多个指标有相关性,但与γ-GT的相关性较显著(r=0.339,P=0.004);慢性胰腺炎组内CA19-9仅与γ-GT有显著的正相关(r=0.570,P=0.006);急性胰腺炎组内,CA19-9与TBA、DBIL、ALT、AST、γ-GT及ALP均有显著的正相关(r>0.5,P<0.01)。胰腺癌、急慢性胰腺炎患者存在不同程度的肝功能损害,因此,同时测定CA19-9和肝功能各生化指标对胰腺癌和急慢性胰腺炎具有一定的辅助诊断价值。To explore the clinical value of detection of CA19-9 and liver function index in the differential diagnosis of pancreatitis and pancreatic cancer,the serum CA19-9 and liver function indexes in 70 patients with pancreatic cancer,43 patients with acute pancreatitis,25 patients with chronic pancreatitis and 65 healthy volunteers were measured by ROCHE Electrochemiluminescence immunoassay and HITACHI 7600 respectively.The results showed that the serum TBIL and ALT level had no statistically difference in all groups（P0.05）.However,the serum ALB levels were significantly lower（P0.01） and CA19-9,TBA,DBIL,AST,γ-GT and ALP levels were significantly higher（P0.01） in patients with pancreatic cancer and pancreatitis than that of in control group（P0.01）.The CA19-9 and ALB levels were significantly higher（P0.01） and γ-GT levels were significantly lower（P0.05） in patients with pancreatic cancer than that of in patients with acute pancreatitis.Compared with chronic pancreatitis,only the CA19-9 level were significantly higher（P0.01） in patients with pancreatic cancer.There was a positive correlation between CA19-9 and γ-GT levels in patients with pancreatic cancer（r=0.339,P=0.004） and patients with chronic pancreatitis（r=0.570,P=0.006）.In patients with acute pancreatitis,CA19-9 levels had positive correlations with TBA,DBIL,ALT,AST,γ-GT and ALP.Detection of CA19-9 and liver function simultaneously could be helpful to differential diagnosis of pancreatic cancer and chronic pancreatitis.

关 键 词：胰腺癌 胰腺炎 CA19-9 肝功能生化指标 相关性 

分 类 号：R735.9[医药卫生—肿瘤]