乳腺癌的病例对照研究  

Case-Control Study on Breast cancer

作　　者：崔静[1,2] 沈福民[1,2] 江峰[1,2] 王云飞[1,2] 边建超[1,2] 沈镇宙[1,2] 

机构地区：[1]上海医科大学流行病教研室 [2]上海医科大学附属肿瘤医院

出　　处：《实用预防医学》1999年第3期163-165,共3页Practical Preventive Medicine

摘　　要：目的进一步探讨和证实乳腺癌的危险因素。方法对上海市１３４名乳腺癌患者进行了１∶１配对的病例对照研究。结果月经初潮年龄、是否怀孕、初产年龄、是否哺乳、良性乳腺病、乳腺癌家族史、教育年限、行经期等危险因素与乳腺癌的发生有关。多因素条件Ｌｏｇｉｓｔｉｃ回归分析显示月经初潮年龄、初产年龄、良性乳腺病、乳腺癌家族史等因素最终进入模型。进一步对乳腺癌病人进行绝经前后的分组分析，绝经前乳腺癌的危险因素包括月经初潮年龄、初产年龄、良性乳腺病，而绝经后危险因素则包括初产年龄、行经期和体重。因素之间经检验无两两交互作用。结论提示绝经前与绝经后乳腺癌在发病上存在一定差异，但需要进一步的研究加以证实。Objective In order to probe and clarify the potential environmental contributions to the occurrence of breast cancer. Methods A 11 matched case control study of breast cancer was conducted on 134 cases and 134 controls in Shanghai. Results The multivariate conditional Logistic regression analysis showed that the risk factors to breast cancer were age of menarche,age of primiparity,history of benign breast diseases and family history of breast cancer. Patients were further subdivided into premenopausal group and postmenopausal one. The former was associated with age of menarche,age of primiparity,and history of benign breast diseases,whereas the latter was related to age of primiparity,menstrual period,and body weight. Conclusion There is variation in the etiology between premenopausal and postmenopausal breast cancer,and needed to be verified by further study.

关 键 词：乳腺癌 病例对照研究 病因 病机 

分 类 号：R737.902[医药卫生—肿瘤]