寒凉和温热药对大鼠脑、垂体和肾上腺内5-羟色胺及去甲肾上腺素神经元和纤维的影响  

The Effect of Coldand Heatnatured Medicines on 5HT andNE Cells and Nerve Fibres in Rat's Brain,Pituitary and Adrenal

作　　者：李良[1] 刘国贞[1] 梁月华[2] 

机构地区：[1]首都医科大学病理解剖学教研室 [2]北京医科大学中西医结合研究室

出　　处：《中国中药杂志》1999年第6期360-362,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：目的：观察寒凉及温热药对大鼠脑及肾上腺内５ＨＴ及ＮＥ神经元以及垂体内神经纤维的影响。方法：采用免疫组织化学的方法进行形态学观察，荧光测定法测量脑内两种递质的变化。结果：寒药组５ＨＴ细胞着色加深，热药组着色变线。ＮＥ细胞的改变与上述相反。结论：寒凉药使脑内５ＨＴ含量增加，ＮＥ含量减少。而温热药使ＮＥ含量增加，５ＨＴ含量减少。形态学改变与机能变化一致。Objective: To study how coldand heatnatured medicines act on 5HT and NE cells in the brain,pituitary and adrenal of rats. Method:Based on immunohistochemical method,the specific antiTH and anti5HT sera were used to observe the changes of 5HT and NE cells in brain and adrenal as well as fibres in pituitary.The contents of these two transmitters in brain were also determined by fluoriphotometry. Results: Coldnatured medicines made the staining of 5HT cells deeper and NE cells lighter,while heatnatured medicines act by contraries. Conclusion: Coldnatured medicines increase the content of 5HT in brain and decrease the content of NE,while heatnatured medicines work the otherway yound.The morphologic changes are conistent with the functional ones.

关 键 词：5-HT神经细胞 寒凉 温热 中药 免疫组化 药理 

分 类 号：R285.5[医药卫生—中药学]