博宁加化疗、放疗治疗肺癌骨转移疗效观察  

A Clinical Trial of Bonin in Bone Metastases of Lung Cancer

作　　者：张树才[1] 刘桂梅[1] 胡范斌 范晓方 杨新杰[1] 顾艳斐[1] 吴卫华 王群会[1] 

机构地区：[1]北京结核病胸部肿瘤研究所肿瘤内科

出　　处：《中国肿瘤临床》1999年第6期445-447,共3页Chinese Journal of Clinical Oncology

摘　　要：目的：观察博宁对肺癌骨转移的止痛效果。方法：应用博宁治疗及放射治疗对照研究。结果：４０例博宁治疗组患者骨痛的止痛总有效率为８７５％，显效率达５００％。其中，单用博宁组有效率为８４６％，博宁合并放疗组有效率为９１６％，博宁合并化疗组有效率为８６７％，三组间止痛效果无显著性差异（Ｐ＞００５）。４０例单纯放射治疗的骨转移患者止痛总有效率为８２５％，显效率为３５０％。博宁应用中除少数患者出现胃肠道反应外，无明显其他毒副反应发生。结论：博宁是一种安全、有效的新一代双膦酸盐制剂，可与放疗、化疗联合应用于肺癌骨转移患者的治疗中。Objective: To evaluate the therapeutic effect of Bonin (Disodium Pamidronate) for bone metastases of lung cancer Methods: Using a randomized clinical study of Bonin with radiotherapy Results: The overall effective rate of Bonin for bone pain in the 40 patients with bone metastases of lung cancer was 875%, the complete response was 500%as compared to the RR of 846%in the Bonin therapy alone group and 916%in the combination group of Bonin with radiotherapy and 867%in the combination group of Bonin with chemotherapy The differences were not statistically significant (P >005) The effective rate of radiotherapy alone for bone pain in the 40 patients with bone metastases of lung cancer was 825%, the complete response rate was 350% Very mild gastrointestinal side-effects such as nausea in the Bonin therapy group were observed Conclusion: Bonin is a generation of bisphosphonates and could be used in patients with bone metastases from lung cancer in combination with radiotherapy and chemotherapy

关 键 词：肺癌 骨转移 博宁 放射治疗 治疗 

分 类 号：R734.205[医药卫生—肿瘤]