雷莫司琼改善顺铂治疗大肠癌186例所致呕吐的疗效观察  

THERAPEUTIC EFFECT OF RAMOSETRON ON TREATING VOMITING INDUCED BY CISPLATIN CHEMOTHERAPY IN 186 CASES WITH COLON CANCER

作　　者：董虹亮[1] 夏冬[1] 梁建群[1] 

机构地区：[1]四川泸州医学院附属医院普外科,泸州646000

出　　处：《现代预防医学》2010年第16期3186-3187,共2页Modern Preventive Medicine

摘　　要：[目的]观察雷莫司琼改善以顺铂为主的化疗方案治疗大肠癌所引起的呕吐症状的临床疗效。[方法]186例大肠癌患者随机分为两组,治疗组用雷莫司琼0.3mg在使用药物化疗前30min静脉推注,对照组用胃复安20mg在使用药物化疗前30min肌注,21d为1个周期,连续观察5d,3周期后评定疗效。[结果]治疗组对呕吐的控制有效率CR+PR为90.57%,远远高于对照组的有效率CR+PR为58.75%,两组差异有统计学意义(P﹤0.05)。[结论]雷莫司琼能更好地改善以顺铂为主的化疗方案,治疗大肠癌所引起的呕吐等上消化道症状。[Objective] To observe the therapeutic effect of ramosetron on treating vomiting induced by cisplatin chemotherapy in 186 patients with colon cancer. [Methods] 186 patients with testified colon cancer undergoing chemotherapy regimens including cisplatin were randomly divided into group A（ramosetron was given intravenously 30 minutes before chemotherapy in a dose of 0.3 mg） and group B（metoclopramide was given intramuscularly 30 minutes before chemotherapy in a dose of 20 mg） . We set 21 days as a cycle,and after 3 cycles we assessed therapeutic effect. [Results] The effective rates,complete response（CR） plus partial response（PR） of group A and B were 90.57% and 58.75%,respectively. There was an obvious statistical difference in the 2 groups（P﹤0.05） . [Conclusion] Ramosetron is effective in treating gastrointestinal reaction,especially vomiting,caused by chemotherapeutic drugs including cisplatin.

关 键 词：雷莫司琼 顺铂 大肠癌 呕吐 

分 类 号：R735.34[医药卫生—肿瘤] R969.4[医药卫生—临床医学]